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Short-term toxicity to aquatic invertebrates

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Description of key information

The immobilisation potential of the test item to Daphnia magna was determined in an OECD guideline 202 test. The EC 50 was determined to be 43 mg/L. 

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
43 mg/L

Additional information

Key-study

The immobilisation potential of the test item to Daphnia magna was determined in an OECD guideline 202 test. Test compound was tested at 4.3, 9.4, 20.7, 45.5 and 100 mg/L. Control was dilution water without test compound. Potassium chromate was used as a positive control substance at test concentrations of 0.58, 1.0, 1.8, 3.2, and 5.8 mg/L. A static test was conducted for 48 h in glass beakers (50 mL volume). EC10 and EC50 values were calculated by probit analysis. The 24 h and 48 h EC100 values were determined directly from the test results. The EC10 value was determined to be 33 mg/L after 48 h. The EC50 was determined to be 43 mg/L after 48 h (Confidence interval p=95 %: 40-46). The EC100 was determined to be 100 mg/L.

A read across approach was applied in addition for short-term toxicity to aquatic invertebrates using data of symmetrical 2,2-dimethyl-3-(3-methylphenyl)-propanol (CAS 103694 -68 -4) as this substance was considered to show similar ecotoxicological properties as compared to the test item. For further justification please refer to IUCLID section 13.

Read-across

The 48 h acute toxicity of the read across substance 2,2 -dimethyl-3-(3-methylphenyl)-propanol to Daphnia magna was studied under static conditions according to OECD guideline 202. Daphnids were exposed to the test item (CAS 103694-68-4) at nominal concentrations of 1, 5, 10, 15, 25, 37.5 and 50 mg/L. No analytical monitoring was done. Mortality effects were observed during the study. The 48 h EC50 was determined to be 19 mg/L, the EC100 was determined to be 37.5 mg/L and the EC0 was 1 mg/L.