Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-058-1 | CAS number: 77-78-1
Carcinogenicity
Administrative data
- Endpoint:
- carcinogenicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Year:
- 1 972
- Bibliographic source:
- IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work), p. V4 274 (1974).
Materials and methods
Test material
- Reference substance name:
- Dimethyl sulphate
- EC Number:
- 201-058-1
- EC Name:
- Dimethyl sulphate
- Cas Number:
- 77-78-1
- Molecular formula:
- C2H6O4S
- IUPAC Name:
- dimethyl sulfate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- other: unspecified oil
- Details on exposure:
- Among 8 BD rats given weekly sc doses of 16 mg/kg bw in oil (total dose, 784 mg/kg bw).
Among 12 BD rats receiving 8 mg/kg bw in oil weekly for 394 days (total dose, 466 mg/kg bw) - Duration of treatment / exposure:
- 394 days
- Frequency of treatment:
- weekly
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
16 mg/kg bw
Basis:
no data
- Remarks:
- Doses / Concentrations:
8 mg/kg bw
Basis:
no data
Results and discussion
Results of examinations
- Details on results:
- Among 8 BD rats given weekly sc doses of 16 mg/kg bw in oil (total dose, 784 mg/kg bw).. 4/6 survivors developed local sarcomas within 236-414 days, 1 with metastases to lung.
Among 12 BD rats receiving 8 mg/kg bw in oil weekly for 394 days (total dose, 466 mg/kg bw).. 7/11 showed local sarcomas, 3 of which had metastasized to lung and regional lymph nodes. Mean tumor induction time was 500 days. One rat liver carcinoma. No control data were reported.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
