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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
repeated dose toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
No information
Author:
Schlögel
Year:
1972
Bibliographic source:
Schlögel (1972) Med. Inaug.-Diss., Würzburg, zitiert in: Toxikologisch-arbeitsmedizinische Begründungen von MAK-Werten, Verlag Chemie (1971).

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Dimethyl sulphate
EC Number:
201-058-1
EC Name:
Dimethyl sulphate
Cas Number:
77-78-1
Molecular formula:
C2H6O4S
IUPAC Name:
dimethyl sulfate

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Duration of treatment / exposure:
15 moons
Frequency of treatment:
6h/day, 2days/week
Doses / concentrations
Remarks:
Doses / Concentrations:
0.5 ppm
Basis:
no data

Results and discussion

Results of examinations

Details on results:
Starke Gewichtseinbusse, schwere entzündliche Veränderungen in Nase und Lunge, erhöhte Absterberate.

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion