Registration Dossier
Registration Dossier
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EC number: 911-302-5 | CAS number: -
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Liquid chromatography with a mass spectrometer is used to determine the hydrolysis rate of the test substance.
With LC/MS a direct method is used to measure the amounts of Mono-and Diester, which will remain after incubation in case of hydrolysis. No decreases > 10% of Mono- and Diester have been detected at pH 7 and 9. At pH 4 the results are in the range of uncertainness of the measuring method; at pH 2 the expected hydrolysis takes place.
Therefore the hydrolysis rate is:
Hydrolysis rate: no hydrolysis observed at pH 7 and 9
Hydrolysis approx. 10% at pH 4*
Hydrolysis observed > 10 % at pH 2
*Due to the relative high uncertainty of the analysis method, a clear statement "higher or lower" than 10% is not possible.
Key value for chemical safety assessment
Additional information
Liquid chromatography with a mass spectrometer is used to determine the hydrolysis rate of the test substance.
With LC/MS a direct method is used to measure the amounts of Mono-and Diester, which will remain after incubation in case of hydrolysis. No decreases > 10% of Mono- and Diester have been detected at pH 7 and 9. At pH 4 the results are in the range of uncertainness of the measuring method; at pH 2 the expected hydrolysis takes place.
Therefore the hydrolysis rate is:
Hydrolysis rate: no hydrolysis observed at pH 7 and 9
Hydrolysis approx. 10% at pH 4*
Hydrolysis observed > 10 % at pH 2
*Due to the relative high uncertainty of the analysis method, a clear statement "higher or lower" than 10% is not possible.
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