Registration Dossier
Registration Dossier
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EC number: 943-007-2 | CAS number: -
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects on aquatic algae up to the limit of water solubility, read across.
Key value for chemical safety assessment
Additional information
Data on the acute toxicity of the target substance Fatty acids, C12-18, even numbered, 3-methylbutyl esters (CAS 1314763-50-2) to aquatic algae is not available. The assessment was therefore based on studies conducted with the structurally similar substances Isopropyl myristrate (CAS 110-27-0) and Fatty acids, C8 -16, 2-ethylhexyl esters (CAS 135800-37-2) as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Further justification is given within the overall summary chapter 6.1 and within the analogue justification section 13.
The toxicity of the source substance Isopropyl myristrate (CAS 110-27-0) to Desmodesmus subspicatus was tested according to EU Method C.3 and to GLP as a limit test (Rieche, 1995). No effects on cell growth were stated at concentrations above the water solubility (ErC50 (72 h) > 0.05 mg/L) in the filtered emulsion of the test medium, while presumably physical effects were observed in the emulsion without filtration (ErC50 < 100 mg/L, nominal).
In a second study the acute toxicity of the source substance Fatty acids, C8 -16, 2-ethylhexyl esters (CAS 135800-37-2) was investigated in a study following EU-Method C.3 with (Wierich, 1998). The toxicity of the substance to Scendesmus subspicatus was tested in filtered and unfiltered solution (100 mg/L) respectively. In the unfiltered test solution the algal growth was inhibited (inhibition up to 75.7%). This observed inhibition was related to physical effects of the undissolved test solution. Whereas the algal growth was not affected in the filtered test solutions and thus no effects up to the limit of water solubility were observed. The reported EL50 (72 h) was > 100 mg/L.
Based on the results of the read across substance toxic effects of Fatty acids, C12-18, even numbered, 3-methylbutyl esters (CAS 1314763-50-2) to aquatic algae are not expected.
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