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EC number: 943-007-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Data on the aquatic toxicity of Fatty acids, C12-18, even
numbered, 3-methylbutyl esters (CAS 1314763-50-2) are not available.
In accordance with Annex XI, 1.5, of Regulation (EC) No 1907/2006,
read-across to the structurally related substances Isopropyl myristate
(CAS 110-27-0), Isopropyl palmitate (CAS 142-91-6) and Fatty acids, C8
-16, 2-ethylhexyl esters (CAS 135800-37-2) was conducted to fulfil the
standard information requirements. In accordance with Article 13 (1) of
Regulation (EC) No 1907/2006, "information on intrinsic properties of
substances may be generated by means other than tests, provided that the
conditions set out in Annex XI are met.” In particular for aquatic
toxicity, information shall be generated whenever possible by means
other than vertebrate animal tests, which includes the use of
information from structurally related substances (grouping or
read-across). According to Annex XI, Item 1.5, of Regulation (EC) No
1907/2006 substances can be considered to be similar if their
physicochemical, toxicological and ecotoxicological properties are
likely to be similar or follow a regular pattern as a result of
structural similarity.
The target and the source substances are esters of a branched
alcohol with a carboxylic fatty acid chain.. The fatty acid moiety of
the target substance comprises linear carbon chain lengths of C12-C18
esterified with isopentanol. The source substances are C8 – C18 linear
fatty acids esterified with branched C3-C8 alcohols. Target and source
substances are characterised by a low water solubility, low vapour
pressure and high log Koc. Thus, the substances are expected to have a
similar environmental fate and ecotoxicity profile.
The available short-term and long-term studies indicate that the source
substances are not acutely toxic to aquatic organisms up to the limit of
water solubility.
In accordance with Regulation (EC) No 1907/2006, Annex XI, 1.5, grouping and read-across the target substance Fatty acids, C12-18, even numbered, 3-methylbutyl esters (CAS 1314763-50-2) is not considered to be harmful to aquatic organisms based on the results of the available read across studies conducted with fish, aquatic invertebrates and algae and long-term results on toxicity to aquatic invertebrates.
Experimental data on the acute toxicity of the read-across substance Isopropyl myristate (CAS 110-27-0) are available for fish, Daphnia and algae. No toxicity of the substance was determined up to the limit of water solubility. Comparable results were determined for the second read across Isopropyl palmitate (CAS 142-91-6). The available acute toxicity test on fish and aquatic invertebrates determined L(E)C50 values >100 mg/L. The available studies on the acute toxicity of the read across substance Fatty acids, C8 -16, 2-ethylhexyl esters (CAS 135800-37-2) to aquatic algae demonstrated no toxicity of the substance.
Data on chronic toxicity are available for Isopropyl myristate (CAS 110-27-0). The long-term toxicity of the substance to Daphnia magna was tested. An effect on survival and reproduction rate of the daphnids was not observed up to the limit of water solubility (NOELR (21 d) ≥ 100 mg/L). Data on the toxicity to microorganisms are available for Isopropyl myristate (CAS 110-27-0). A growth inhibition of Pseudomonas putida was not observed.
The available acute toxicity data of the read-across substances demonstrate that toxic effects of the target substance Fatty acids, C12-18, even numbered, 3-methylbutyl esters (CAS 1314763-50-2) up to the limit of water solubility are not likely. Consequently, additional acute and chronic testing is omitted. Based on the result from structurally related read-across substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) it can be concluded that Fatty acids, C12-18, even numbered, 3-methylbutyl esters (CAS 1314763-50-2) will not show toxic effects on freshwater organisms up to the limit of the water solubility (WS <0.05 mg/L).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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