ethyl N2-dodecanoyl-.sc.l.sc.-argininate hydrochloride

Flammability

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

flammable solids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2000-03-07

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

A guideline study with GLP.

Qualifier:

according to guideline

Guideline:

EU Method A.10 (Flammability (Solids))

Deviations:

no

GLP compliance:

yes

Specific details on test material used for the study:

L.A.E.
Appearance: White solid
Batch: 2625
Expiry date: April 2001
Purity: 92-94%

Key result

Test procedure:

burning rate test: preliminary screening test

Burning time:

2 min

Remarks on result:

substance does not ignite and propagate combustion either by burning with flame or smouldering along 200 mm of the powder train within the 2 minutes test period

N^α-Lauroyl-L-arginine ethyl ester monohydrochloride (LAE) melted but failed to ignite.

Interpretation of results:

GHS criteria not met

Remarks:

CLP Implementation.

Conclusions:

Nα-Lauroyl-L-arginine ethyl ester monohydrochloride (LAE) is not highly flammable.

Executive summary:

The flammability of N^α-Lauroyl-L-arginine ethyl ester monohydrochloride (LAE) was determined according to EU method A.10. The test substance is not highly flammable.

Reference 2

Endpoint:

substances / mixtures which in contact with water emit flammable gases

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is known to be soluble in water to form a stable mixture

Justification for type of information:

JUSTIFICATION FOR DATA WAIVING
The substance is not classified as flammable in contact with water based on the chemical structure and the experience in handling / use which shows that the substance does not react with water.

Interpretation of results:

non flammable

Remarks:

Migrated information

Reference 3

Endpoint:

pyrophoric solids

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is known to be stable in contact with air at room temperature for prolonged periods of time (days) and hence, the classification procedure does not need to be applied

Justification for type of information:

JUSTIFICATION FOR DATA WAIVING
Practical experience in manufacture and handling shows that the substance does not ignite spontaneously on coming into contact with air at normal temperatures.

Description of key information

The test substance is not highly flammable.

Pyrophoric properties, data waving:

Practical experience in manufacture and handling shows that the substance does not ignite spontaneously on coming into contact with air at normal temperatures.

Contact with water, data waving:

The substance is not classified as flammable in contact with water based on the chemical structure and the experience in handling / use which shows that the substance does not react with water.

Key value for chemical safety assessment

Flammability:

non flammable

Additional information

Key study 1: The flammability of N^α-Lauroyl-L-arginine ethyl ester monohydrochloride was determined according to EU Guideline A.10.

Justification for classification or non-classification

The test substance is not highly flammable.