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EC number: 205-860-2 | CAS number: 156-60-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
Description of key information
Additional information
The cardiac sensitization potential of the test item during acute inhalation exposures to dogs was evaluated. Dogs were exposed to concentrations that ranged from 250000 to 500000 ppm (25 to 50%). All five dogs were sensitized by the test substance. The lowest-adverse-effect-concentration for cardiac sensitization is therefore considered to be 250000 ppm.
The ability of the substance to modulate endocrine system was evaluated by conducting 2 in vitro assays:
- Aromatase (Human Recombinant) Assay and Steroidogenesis (Human Cell Line - H295R).
The Aromatase (Human Recombinant) Assay is a screening assay intended to identify chemicals that may affect the endocrine system by inhibiting catalytic activity of aromatase (CYP 19), the enzyme responsible for the conversion of androgens to estrogens. As per the guideline (OPPTS 890.1200) human recombinant microsomes (Human CYP19 Aromatase +P450 Reductase Supersomes), in the three valid independent runs, the mean % aromatase activity was > 83 % at every soluble concentration tested for the test substance, classifying it as a “non-inhibitor”.
The Steroidogenesis (Human Cell Line - H295R) assay was conducted to evaluate the ability of the test substance, trans 1,2-dichloroethylene, to affect the steroidogenic pathway beginning with the sequence of reactions occurring after the gonadotropin hormone receptors through the production of testosterone and estradiol using the human cell line H295R.
According to Steroidogenesis (Human Cell Line - H295R)-US EPA Guideline (890.1550), trans 1,2-dichloroethylene did not inhibit both testosterone and estradiol, therefore is categorized as ‘negative’ for steroidogenic pathway activity based upon the assay results yielded in this test system from three valid, independent runs.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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