Registration Dossier
Registration Dossier
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EC number: 208-952-0 | CAS number: 548-61-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: test procedure meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
- Principles of method if other than guideline:
- According to ETAD-Subkomitee für Toxikologie 'Empfohlene Methoden zur toxikologischen Untersuchung von Farbstoffen und Hilfsmitteln'.
Treatment of 3 rabbits on the inner side of the ear for 24 hours under occlusive conditions. - GLP compliance:
- no
Test material
- Reference substance name:
- 4,4',4''-methylidynetrianiline
- EC Number:
- 208-952-0
- EC Name:
- 4,4',4''-methylidynetrianiline
- Cas Number:
- 548-61-8
- Molecular formula:
- C19H19N3
- IUPAC Name:
- 4,4',4''-methylidynetrianiline
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 500 mg - Duration of treatment / exposure:
- 24 h
- Observation period:
- directly after treatment and 48h thereafter
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: inner side of the ear
- Type of wrap if used: no details given
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 0h and 48h
- Score:
- 0
Any other information on results incl. tables
No skin reaction was observed.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Executive summary:
In a skin irritation study the test material was applied to the inner side of the ear of 3 white rabbits under occlusive conditions. No signs of skin irritation became obvious directly after treatment and 48 hours thereafter. Thus, the test material did not cause skin irritation under the protocol used. According to EU Regulation 1272/2008 no classification for skin irritation is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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