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Diss Factsheets
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EC number: 200-466-7 | CAS number: 60-27-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
For the assessment of the short-term toxicity of Creatinine to aquatic freshwater organisms two reliable study according to standard guidelines are available. In both studies Creatinine do not induce any negative effects on aquatic freshwater organism.
The acute toxicity of Creatinine on Daphnia magna was determined in a 48 hours static test following the pattern of EEC Commission Directive 92/69, C.2 "Acute Toxicity for Daphnia magna". Animals of Daphnia magna, not more than 24 hours old, were exposed to different concentrations of the test substance in reconstituted water according to ISO 6341. A negative control group was exposed to reconstituted water only. In the test 20 daphnids, divided into 4 replicates (5 daphnia each) were used for each concentration and for the control group. The results show that at a test substance concentration of 1000 mg/L no daphnids were immobilized. Therefore the EC50 of Creatinine is > 1000 mg/L.
A second study was performed in order to evaluate the toxic potential of Creatinine towards Pseudokirchneriella subcapitata according to OECD Guideline No. 201 ("Freshwater Alga and Cyanobacteria, Growth Inhibition Test").Initial concentration of 0.5 × 104 cells/mL in each test vessel, were exposed in a static test system for 72 hours.A static limit test (range-finding test in limit test design) with concentrations of 1.00, 10.0, 100 mg/L and control was performed.Six replicates were tested for the controland the highest test item concentrationand three for the other test item concentrations.After 24, 48 and 72 hours, the cell growth was determined by fluorescence detection. The mean value of the cell concentration was plotted versus time to produce growth curves for each concentration. EC values (ErC50, EyC50, NOEC, LOEC) were calculated.Analytical samples were taken from the highest test item concentration and from the control after 0, 24, 48 and 72 hours. All samples were analysed at 0 and 72 hours to verify the actual test concentration using a validated analytical method.
No inhibitory effects were observed for the test substance Creatinine up to the highest concentration of 100 mg/L (nominal). The EC50-value for growth rate (ErC50) and yield (EyC50) was > 100 mg/L (nominal). The LOEC was determined to be > 100 mg/L (nominal) and the NOEC was determined to be 100 mg/L (nominal) for the parameters growth rate and yield.
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