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Physical & Chemical properties

Density

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Reference
Endpoint:
relative density
Type of information:
experimental study
Adequacy of study:
key study
Study period:
31.03.2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 109 (Density of Liquids and Solids)
Qualifier:
according to guideline
Guideline:
EU Method A.3 (Relative Density)
GLP compliance:
yes (incl. QA statement)
Type of method:
pycnometer method
Key result
Type:
density
Density:
1.39 kg/m³
Temp.:
20.3 °C
Key result
Type:
relative density
Density:
1.39
Temp.:
20.3 °C

Table 1: Pressure readings, calculated volumes and density values obtained for the test item.

Determination

Test

P1(sample) (psig)

P2(sample) (psig)

Volume (cm3)

 

Density (kg/m3)

Mean Density

(kg/m3)

1

A

17.105

5.636

2.589

1.390 x 103

1.387 x 103

B

17.091

5.633

2.601

1.383 x 103

C

17.080

5.628

2.591

1.389 x 103

2

A

17.079

5.707

3.165

1.395 x 103

1.389 x 103

B

17.054

5.702

3.189

1.385 x 103

C

17.068

5.706

3.184

1.387 x 103

Duplicate determinations were performed to ensure a reproducibility of less than ± 20 kg/m3 was obtained.

The mass density of a substance varies with temperature and pressure and this variance is typically negligible for solids. Increasing the temperature of a substance may decrease its density by increasing the volume of that substance. Typical thermal expansion coefficients of

solids are in the order of 10-5 °C-1, and the volumetric expansion of stainless steel (used as the calibration spheres) at 20 °C is approximately 5.2 x 10-5 °C-1. Therefore, a change in temperature of several degrees will have no significant effect on the volume and hence the density of a solid substance. Therefore, it was considered that the difference in temperature between 20.0 °C and normal

laboratory conditions did not have a significant effect on the determined density and therefore the calculated relative density.

Conclusions:
The density of Creatinine (CAS 60-27-5) has been determined to be 1.39 x 10^3 kg/m3 at 20.3 ± 0.5 °C (relative density: 1.39), using a gas comparison pycnometer.
Executive summary:

The density of Creatinine (CAS 60-27-5) has been determined to be 1.39 x 10^3 kg/m3 at 20.3 ± 0.5 °C (relative density: 1.39), using a gas comparison pycnometer, designed to be compatible with Method A3 Relative Density of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 109 of the OECD Guidelines for Testing of Chemicals, 02 October 2012.

Description of key information

The density of Creatinine (CAS 60-27-5) has been determined to be 1.39 x 10^3 kg/m3 at 20.3 ± 0.5 °C

(relative density: 1.39), using a gas comparison pycnometer.

Key value for chemical safety assessment

Relative density at 20C:
1.39

Additional information

The density of Creatinine (CAS 60-27-5) has been determined to be 1.39 x 10^3 kg/m3 at 20.3 ± 0.5 °C (relative density: 1.39), using a gas comparison pycnometer, designed to be compatible with Method A3 Relative Density of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 109 of the OECD Guidelines for Testing of Chemicals, 02 October 2012.