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EC number: 457-670-6 | CAS number: 157859-20-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 October 2004 to 16 December 2004
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- The restrictions were larger area of test substance application than recommended in guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- (area of test substance application was 16 cm2, guideline recommends 6 cm2)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Triisopropylsilyl acrylate
- Cas Number:
- 157859-20-6
- Molecular formula:
- C12H24O2Si
- IUPAC Name:
- Triisopropylsilyl acrylate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Elevage Scientifique des Dombes, F-01400 Chatillon sur Chalaronne, France
- Age at study initiation: 11 weeks (male), 12 weeks (females)
- Weight at study initiation: 2141 g (male), 2194-2198 g (females)
- Housing: Individually in stainless steel cages
- Diet: Pelleted standard Provimi Kliba 3418 rabbit maintenance diet, ad libitum
- Water: Community tap water ad libitum
- Acclimation period: 5 days under laboratory conditions after health examination
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17-23
- Humidity (%): 30-70
- Air changes (per hr): 10-15
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 26-Oct-2004 To: 15-Nov-2004
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml/animal
- Concentration (if solution): 100% - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 14 days
- Number of animals:
- 1 male, 2 females
- Details on study design:
- TEST SITE
- Area of exposure: 16 cm2 on left flank
- % coverage: No data
- Type of wrap if used: Surgical gauze patch covered with a semi-occlusive dressing wrapped around the abdomen and anchored with tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Flushed with lukewarm water
- Time after start of exposure: 4 hours
SCORING SYSTEM: Numerical scoring system listed in Commission Directive 2004/73/EC (based on the Draize score system) approximately 1, 24, 48 and 72 hours, as well as 7, 10 and 14 days after removal of the patch
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 2
- Max. score:
- 8
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 days
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 days
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- Very slight (score 1) to well-defined erythema (score 2) was noted in all animals 1 hour after treatment. Well-defined erythema (score 2) was noted in all animals from the 24- to the 72-hour examination. Very slight (score 1) to well-defined (score 2) erythema was noted in all animals at the 7-day examination and very slight erythema (score 1) persisted in 1 animal up to the 10-day examination. Scaling was noted in 1 animal at the 72-hour examination and in all animals from the 7- to the 14-day examination. No oedema was seen in animal at any timepoint. There were no alterations of the treated skin nor corrosive effects.
- Other effects:
- No clinical signs of systemic toxicity, mortality or effects on body weight.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- In a 4-hour skin irritation study in rabbits, conducted according to OECD test guideline 404 and in compliance with GLP, undiltued tri(isopropyl)silyl acrylate was a skin irritant.
- Executive summary:
Tri(isopropyl)silyl acrylate was tested in an skin irritation test, conducted to OECD test guideline 404 and in compliance with GLP.
Undiluted test material (0.5ml) was applied to the left flank of 3 rabbits for 4 hours and skin was examined for signs of irritation and corrosion 1, 24, 48 and 72 hours, as well as 7, 10 and 14 days after removal of the patch.
Signs of irritation were seen at the 1-, 24-, 48- and 72-hour, 7- and 10-day time points, but these had disappeared by the 14-day time point. Scaling, evident from the 72-hour time point, persisted to the end of the observation period. No corrosive effects were noted.
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