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EC number: 202-905-8 | CAS number: 100-97-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1966
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: old public available literature, non GLP, non Guideline
Data source
Reference
- Reference Type:
- publication
- Title:
- Carcinogenicity and toxicity tests of Hexamethylenetetramine in mice and rats
- Author:
- Della Porta, G.
- Year:
- 1 966
- Bibliographic source:
- Food Cosment. Toxicol. 3, 362-363
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The study was conducted in 1966 before OECD Guidelines existed. Public available literature. No guideline indicated but similar to OECD limit test, but with two doses. For details on method see IUCLID5 materials and methods section.
- GLP compliance:
- no
- Test type:
- other: no data
- Limit test:
- no
Test material
- Reference substance name:
- Methenamine
- EC Number:
- 202-905-8
- EC Name:
- Methenamine
- Cas Number:
- 100-97-0
- Molecular formula:
- C6H12N4
- IUPAC Name:
- 1,3,5,7-tetraazatricyclo[3.3.1.1³,⁷]decane
- Test material form:
- solid: crystalline
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- adult rats were used.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- An 80% aqueous solution was administered by oral intubation.
- Doses:
- 10 g/kg and 20 g/kg
- No. of animals per sex per dose:
- five animals per group (sex not indicated)
- Control animals:
- not specified
- Details on study design:
- Two groups of five rats were given 10 g/kg and 20 g/kg of methenamine as an 80% aqueous solution by oral intubation.
- Statistics:
- not indicated.
Results and discussion
- Preliminary study:
- no data on preliminary study
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 20 000 mg/kg bw
- Sex:
- not specified
- Dose descriptor:
- other: NOAEL
- Effect level:
- >= 20 000 mg/kg bw
- Mortality:
- no mortality observed.
- Clinical signs:
- other: not indicated
- Gross pathology:
- not indicated
- Other findings:
- not indicated
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 of methenamine is > 20000 mg/kg bw after single oral administration to rats.
- Executive summary:
In an acute oral toxicity study, 2 groups of adult Wistar rats (5 animals per dose) were given a single oral dose of methenamine (80 %) in water at doses of 10000 and 20000mg/kg bw.
Oral LD50 > 20000 mg/kg bw
All animals survived.
Hexamethylenetetramine is of practically no toxicity based on the LD50 in rats.
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