Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 204-661-8 | CAS number: 123-91-1
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Human study, case report in which basic data were given.
Data source
Reference
- Reference Type:
- publication
- Title:
- Allergic contact dermatitis from dioxane in a solvent for cleaning metal parts
- Author:
- Fregert, S.
- Year:
- 1 974
- Bibliographic source:
- Cont. Derm. Newsletter 15, 438.
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Patch- test
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,4-dioxane
- EC Number:
- 204-661-8
- EC Name:
- 1,4-dioxane
- Cas Number:
- 123-91-1
- Molecular formula:
- C4H8O2
- IUPAC Name:
- 1,4-dioxane
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed: 1
- Sex: male - Route of administration:
- dermal
- Details on study design:
- One 52-year old man, who developed dermatitis on his left hand after daily dipping in a 1,4-dioxane containing solvent for 3 years, scored positive in a patch test (0.5% in water).
Results and discussion
- Results of examinations:
- One 52-year old man, who developed dermatitis on his left hand after daily dipping in a 1,4-dioxane containing solvent for 3 years, scored positive in a patch test (0.5% in water).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
