Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-742-5 | CAS number: 110-16-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Toxicology of the eye
- Author:
- Grant J (ed)
- Year:
- 1 986
- Bibliographic source:
- In: Toxicology of the eye, 3rd ed., 574. Springfield, IL: Charles C. Thomas
- Reference Type:
- review article or handbook
- Title:
- Final report on the Safety Assessment of Maleic Acid
- Author:
- American College of Toxicology
- Year:
- 2 007
- Bibliographic source:
- International Journal of Toxicology 26, 125-130
Materials and methods
Test material
- Reference substance name:
- Maleic acid
- EC Number:
- 203-742-5
- EC Name:
- Maleic acid
- Cas Number:
- 110-16-7
- Molecular formula:
- C4H4O4
- IUPAC Name:
- but-2-enedioic acid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Test system
- Amount / concentration applied:
- 10 % to 1 %
- Duration of treatment / exposure:
- 30 sec (10 %) to 2 min (1 %)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: permanent corneal opacity and vascularization
- Basis:
- other: no data
- Remarks on result:
- other: test substance concentration 10 %, pH 1.0
- Irritation parameter:
- other: transient corneal cloudiness
- Basis:
- other: no data
- Remarks on result:
- other: test substance concentration 1 %, pH 1.0
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- In the eyes of rabbits, maleic acid caused permanent corneal opacity and vascularization at a concentration of 10% (pH= 1.0) after 30 seconds, and transient corneal cloudiness at a concentration of 1 % (pH = 1.0) after 2 minutes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
