Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 931-322-8 | CAS number: 68131-74-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- cytotoxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Comparative Cytotoxicity of DQl2 Quartz and Fly Ash Particles from Coal Combustion
- Author:
- Hill, J.O. and Hobbs, C.H.
- Year:
- 1 982
- Bibliographic source:
- Toxicology Letters, 10 (1982) 399-403
Materials and methods
- Principles of method if other than guideline:
- Fly ash samples obtained from different coal combustors were tested for cytotoxicity to alveolar macrophages in vitro by measuring the release of lactate dehydrogenase into the culture media.
- GLP compliance:
- no
- Type of method:
- in vitro
Test material
- Reference substance name:
- Ashes (residues), coal
- EC Number:
- 931-322-8
- Cas Number:
- 68131-74-8
- Molecular formula:
- Not applicable (UVCB substance)
- IUPAC Name:
- Ashes (residues), coal
- Details on test material:
- - Name of test material (as cited in study report): Baghouse filter or electrostatic precipitator samples of fly ash were obtained from six different coal combustors throughout the United States. The in vitro cytotoxicities of the ashes were compared with a positive reference standard, DQ12 quartz, obtained from the Dörentrup deposits in the Federal Republic of Germany.
Constituent 1
Test animals
- Species:
- dog
- Strain:
- Beagle
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: in medium
- Vehicle:
- other: culture medium
- Duration of treatment / exposure:
- 24 h
- Frequency of treatment:
- single
- Post exposure period:
- not applicable
- No. of animals per sex per dose:
- not applicable
Results and discussion
Any other information on results incl. tables
Ashes from six different coal combustors were tested. Ash samples derived from the combustion of coal were not toxic to macrophages in vitro at concentrations up to 200 µg/106 cells (1000 µg/culture). In addition, ash derived from different coals burned in a single combustor were also not cytotoxic. Ashes derived from the combustion of Montana Rosebud sub-bituminous (3 samples), Texas Lignite (1 sample), and Western Kentucky Bituminous (1 sample) in an atmospheric fluidized bed combustor were similarly nontoxic. At the same concentration, the quartz induced the release of 56% of all LDH recoverable by cell sonication (EC50 = 100 pg/106 cells).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.