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EC number: 930-915-9 | CAS number: 1318-02-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Federal Hazardous Substances Labeling Act
- Version / remarks:
- CFR, Part 191, Chapter I. Title 21
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- fixed concentration procedure
- Limit test:
- no
Test material
- Reference substance name:
- Zeolite, cuboidal, crystalline, synthetic, non-fibrous
- EC Number:
- 930-915-9
- Cas Number:
- 1318-02-1
- Molecular formula:
- M2/nO • Al2O3 • ySiO2 • wH2O (n is the valency of the cation M, predominantly Na, y can range from 0.64 to 8.8, and w is the number of water molecules (general formula) Na: 1.34 - 24.02%, Al: 2.20 - 39.51%, Si: 15.52 - 68.64% (general composition); additionally, depending on the water quality: Ca, Mg and K might be present below 6%
- IUPAC Name:
- Zeolite, cuboidal, crystalline, synthetic, non-fibrous
- Test material form:
- solid: particulate/powder
- Remarks:
- no surface treatment
Constituent 1
- Specific details on test material used for the study:
- Crystalline Aluminosilicate, very fine white powder, coded CH-216-110-1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Twenty (20) Sprague-Dawley derived rats weighing between 200 and 225 grams were obtained from Charles River Breeding Laboratories. The animals were caged in groups of ten (10) and given Charles River Cubed Diet and tap water ad libitum. The animals were allowed at least five (5) days to accomodate to the laboratory conditions prior to being assigned to the study.
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- clean air
- Details on inhalation exposure:
- The system operated as follows: The glass flask, auger assembly and dust ejector assembly were mounted on a vibrating platform. Vibration was produced by an electrical vibrator attached to the platform. Vibration from the platform maintained a flow of powder from the flask to the auger assemble. Rotational speed of the auger controlled the rate of compound feed to the dust ejector assembly. Dry, filtered, compressed air applied to the jet in the dust ejector created a negative pressure in the funnel which pulled the powder down into a high velocity air stream. This dust laden air was then led to the 56-liter all-glass exposure chamber. By observing the rate at which powder dropped into the funnel it was possible to insure that the system was operating correctly throughout the exposure periods.
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- ca. 1 h
- Remarks on duration:
- s. "Details on study design" 2nd paragraph
- Concentrations:
- Mean actual concentrations of three measurements:
18.3 mg/l (group I)
2.4 mg/l (group II) - No. of animals per sex per dose:
- 10 (males only)
- Control animals:
- no
- Details on study design:
- Prior to the actual exposures, the generator's powder output was calibrated in terms of the.auger speed. This was accomplished by collecting, for a known time, the powder as it dropped from the tip of the auger and then weighing the collected powder. This was repeated a number of times at various auger speeds. From the resulting calibration curve (mg/min. vs rpm), the air pressure applied to the dust ejector was selected such that the resulting air flow would yield the nominal dust concentration in the exposure chamber.
Since the selected chamber air flow rate of 13 L/min used for Group II resulted in a significant equilibration time for a 56-liter chamber, the actual duration of exposure for Group II was extended to seventy-four (74) minutes so that the CT (concentration X time) would be equivalent to a sixty (60) minute exposure to a constant concentration.
In addition to calculating the nominal exposure concentrations, the actual exposure concentrations were determined during each exposure. This was accomplished by drawing a known volume of chamber air through pre-weighed glass fiber filters which were then reweighed. Three (3) such samples were taken during each one-hour exposure.
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LC0
- Effect level:
- >= 18.3 mg/L air (analytical)
- Exp. duration:
- 60 min
- Mortality:
- no mortality
- Body weight:
- Body weights recorded prior to exposure and seven (7) and fourteen (14) days post-exposure did not reveal any effects related to the experimental compound.
- Gross pathology:
- All animals were necropsied following the fourteen (14) day observation period, and all organs were observed for gross abnormalities. There were no gross abnormalities which could be related to the exposure conditions.
Any other information on results incl. tables
There were no signs of toxicity in either exposure group during the exposure or the fourteen (14) day observation period.
Applicant's summary and conclusion
- Conclusions:
- There were no signs of toxicity in either exposure group during the exposure or the fourteen (14) day observation period. Therefore, the substance would be classified as non-toxic according to the definitions of Part 191, Chapter 1, Title 21 of the CFR, when administered via the inhalation route as an aerosol.
- Executive summary:
The purpose of this study was to evaluate the acute inhalation toxicity of Crystalline Aluminosilicate according to requirements of the Federal Hazardous Substances Labeling Act, CFR, Part 191, Chapter I. Title 21. Two groups of ten (10) male rats were exposed for approximately one hour to actual mean concentrations of 2.4 and 18.3 mg/l. No signs of toxicity were observed.
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