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EC number: 930-915-9 | CAS number: 1318-02-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Jan. 8-12 and Jan.23-27, 2021
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- other: ISO 10872
- Version / remarks:
- 2020
- Deviations:
- no
- Remarks:
- All validity criteria were met in the controls of all tests.
- GLP compliance:
- no
- Remarks:
- As these data are not used to assess extrapolation to humans, a study according to GLP was not regarded as necessary.
- Specific details on test material used for the study:
- • Chemical name: Aluminium Magnesium Vanadium Oxide
• Trade name: Na Y (Y zeolite)
• Acronym in Report: NaY
• Batch number: RZ200094/1
• Composition: Aluminosilicate (Al/Si ~ 0.3)
• CAS No.: 1318-02-1
• Purity: 100 %
• Specific Surface Area (BET): not stated
• Grain size (diameter): 5.723 - Vehicle:
- yes
- Remarks:
- M9 medium
- Test organisms (species):
- other: Caenorhabditis elegans
- Details on test organisms:
- Strain: N2
Genotype: C. elegans wild type
Source: Caenorhabditis Genetic Centre; University of Minnesota; Minneapolis; MN 55455; USA.
Cultivation: C. elegans were cultivated according to ISO 10872. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Test temperature:
- 19.5-20.5 °C
- Nominal and measured concentrations:
- Test 1: 0, 625, 1250, 2500, 5000, 10000 mg/l
Test 2: 0, 1554, 2020, 2626, 3414, 4438, 5769, 7500, 15000 mg/l - Duration:
- 96 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 1 554 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- growth
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 250 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- growth
- Duration:
- 96 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 1 554 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- reproduction
- Key result
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 250 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- reproduction
- Details on results:
- A first test showed that effects of NaY on growth and reproduction mainly occurred between 1,250 mg/l (no significant effect) and 5,000 mg/l (>80% inhibition). Therefore, a second test was performed with more concentration steps in this effect range in order to get a proper dose-response curve and more accurate ECx values.
Compared to the control, first significant inhibitory effect of NaY on nematode growth and reproduction could be observed at nominal concentrations of 1,554 mg/L (p < 0.001; one-way ANOVA [df = 8; growth: F = 58.574; reproduction: 24.651], growth: posthoc Dunnett: p < 0.001; reproduction: posthoc Games-Howell: p < 0.001. Thus, for both toxicity endpoints, a NOEC of 1250 mg/L could be calculated.
If using data of both tests, proper dose-response curves could be established for growth and reproduction, as effects of > 50% inhibition were observed. Based on the logistic function that significantly fitted the dose-response curve to the observed toxicity data, EC10 and EC50 values were calculated as 1,755 and 15,437 mg/L, respectively, for growth and 686 and 2303 mg/L, respectively, for reproduction. NOEC and EC10 values matched quite nicely for both toxicity endpoints. The fact that for growth NOEC < EC10 and for reproduction NOEC > EC10, might be explaind by the considerably lower discriminatory power of growth
compared to reproduction. - Validity criteria fulfilled:
- yes
- Conclusions:
- NOECs for growth and reproduction were both 1,250 mg/l.
- Executive summary:
The toxicity of the Alumininosilicate (NaY Zeolite; NaY) via spiked water, sediment and soil was tested with the nematode Caenorhabditis elegans, using the ISO guideline 10872. In spiked water, NaY inhibited growth or reproduction of C. elegans dose-dependently at concentrations ≥ 1,554 mg/L, with a NOEC at 1,250 mg/L.
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Jan. 8-12, 2021
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- other: ISO 10872
- Version / remarks:
- 2020
- Deviations:
- no
- Remarks:
- All validity criteria were met in the controls of all tests.
- GLP compliance:
- no
- Remarks:
- As these data are not used to assess extrapolation to humans, a study according to GLP was not regarded as necessary.
- Specific details on test material used for the study:
- • Chemical name: Alumininosilicate
• Trade name: Köstrolith (X Zeolite)
• Acronym in Report: Kt
• Batch number: 2006090001
• Composition: Aluminosilicate (Al/Si ~ 0.7)
• CAS No.: 1318-02-1
• Purity: 100 %
• Specific Surface Area (BET): not stated
• Grain size (diameter): 3.432 μm - Vehicle:
- yes
- Remarks:
- M9 medium
- Test organisms (species):
- other: Caenorhabditis elegans
- Details on test organisms:
- Strain: N2
Genotype: C. elegans wild type
Source: Caenorhabditis Genetic Centre; University of Minnesota; Minneapolis; MN 55455; USA.
Cultivation: C. elegans were cultivated according to ISO 10872. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Test temperature:
- 19.5-20.5 °C
- Nominal and measured concentrations:
- 0, 312.5, 625, 1250, 2500, 5000, 10000 mg/l
- Duration:
- 96 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 625 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- growth
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 313 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- growth
- Duration:
- 96 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 625 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- reproduction
- Key result
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 313 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- reproduction
- Details on results:
- Compared to the control, first significant inhibitory effect of Kt on nematode growth and reproduction could be observed at nominal concentrations of 625 mg/L (p < 0.001; one-way ANOVA [df = 6; growth: F = 88.726; reproduction: 53.376], growth: posthoc Dunnett: p < 0.001;
reproduction: posthoc Games-Howell: p < 0.001). Thus, for both toxicity
endpoints, a NOEC of 313 mg/L could be calculated.
Proper dose-response curves could be established for growth and reproduction, as effects of > 50% inhibition were observed. Based on the logistic function that significantly fitted the dose-response curve to the observed toxicity data, EC10 and EC50 values were calculated as 351 and 2,086 mg/L, respectively, for growth and 289 and 777 mg/L, respectively, for reproduction. NOEC and EC10 values matched quite nicely for both toxicity endpoints. Inhibition values at NOEC were very close (growth: 7.4%) or lower (reproduction: 10.5) than the calculated %MDD. - Validity criteria fulfilled:
- yes
- Conclusions:
- NOECs for growth and reproduction were both 313 mg/l.
- Executive summary:
The toxicity of the zeolite Köstrolith (Kt) via spiked water, sediment and soil was tested with the nematode Caenorhabditis elegans, using the ISO guideline 10872. In spiked water, Kt inhibited growth or reproduction of C. elegans dose-dependently at concentrations ≥ 625 mg/L, with a NOEC at 313 mg/L.
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Jan. 8-12 and Jan. 15-19, 2021
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- other: ISO 10872
- Version / remarks:
- 2020
- Deviations:
- no
- Remarks:
- All validity criteria were met in the controls of all tests.
- GLP compliance:
- no
- Remarks:
- As these data are not used to assess extrapolation to humans, a study according to GLP was not regarded as necessary.
- Specific details on test material used for the study:
- • Chemical name: Aluminosilicate
• Trade name: Zeocros (Y Zeolite)
• Acronym in Report: Zeo
• Batch number: 2020-531
• Composition: Aluminosilicate (Al/Si ~ 0.8)
• CAS No.: 1318-02-1
• Purity: 100 %
• Specific Surface Area (BET): not stated
• Grain size (diameter): 1.115 μm - Vehicle:
- yes
- Remarks:
- M9 medium
- Test organisms (species):
- other: Caenorhabditis elegans
- Details on test organisms:
- Strain: N2
Genotype: C. elegans wild type
Source: Caenorhabditis Genetic Centre; University of Minnesota; Minneapolis; MN 55455; USA.
Cultivation: C. elegans were cultivated according to ISO 10872. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Test temperature:
- 19.5-20.5 °C
- Nominal and measured concentrations:
- Test 1: 0, 313, 625, 1250, 2500, 5000 mg/l
Test 2: 0, 62.5, 125, 250, 500, 1000, 2000 mg/l - Duration:
- 96 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 313 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- growth
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 250 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- growth
- Duration:
- 96 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 313 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- reproduction
- Key result
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 250 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- reproduction
- Details on results:
- A first test showed that strong effects of Zeo on growth and reproduction already occurred at the lowest tested concentration of 313 mg/l (e.g. >70% inhibition of reproduction). Therefore, a second test was performed with lower concentration steps in order to get a proper doseresponse.
Compared to the control, first significant inhibitory effect of Zeo on nematode growth and reproduction could be observed at a nominal concentration of 313 mg/L in the first test (water test 1: p < 0.001; one-way ANOVA [df = 5; growth: F = 92.935; reproduction: 92.739], growth:
posthoc Dunnett: p < 0.001; reproduction: posthoc Games-Howell: p < 0.001) and at a nominal concentration of 500 mg/L in the second test (water test 2: p < 0.001; oneway ANOVA [df = 6; growth: F = 43.102; reproduction: 32.346], growth: posthoc Dunnett: p < 0.001; reproduction: posthoc Games-Howell: p < 0.001). For both toxicity endpoints, a NOEC of 250 mg/L could be calculated (water test 2: growth: posthoc Dunnett: p
= 0.947; reproduction: posthoc Games-Howell: p = 0.846).
If using data of both tests, proper dose-response curves could be established for growth and reproduction. Based on the logistic function that significantly fitted the dose-response curve to the observed toxicity data, EC10 and EC50 values were calculated as 165 and 980 mg/L, respectively, for growth and 142 and 342 mg/L, respectively, for reproduction. NOEC and EC10 values matched quite nicely for both toxicity endpoints. %MDD could properly predict first significant effects of growth and reproduction. - Validity criteria fulfilled:
- yes
- Conclusions:
- NOECs for growth and reproduction were both 250 mg/l.
- Executive summary:
The toxicity of the zeolite Zeocros (Zeo) via spiked water, sediment and soil was tested with the nematode Caenorhabditis elegans, using the ISO guideline 10872. In spiked water, Zeo inhibited growth and reproduction of C. elegans dose-dependently at concentrations ≥ 313 mg/L, with a NOEC at 250 mg/L.
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Jan. 8-12 and Jan. 15-19, 2021
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- other: ISO 10872
- Version / remarks:
- 2020
- Deviations:
- no
- Remarks:
- All validity criteria were met in the controls of all tests.
- GLP compliance:
- no
- Remarks:
- As these data are not used to assess extrapolation to humans, a study according to GLP was not regarded as necessary.
- Specific details on test material used for the study:
- • Chemical name: Aluminosilicate
• Trade name: Sylosiv A4 (A Zeolite)
• Acronym in Report: Syl
• Batch number: 1000361205
• Composition: Aluminosilicate (Al/Si ~ 1)
• CAS No.: 1318-02-1
• Purity: 100 %
• Specific Surface Area (BET): not stated
• Grain size (diameter): 8.687 μm - Vehicle:
- yes
- Remarks:
- M9 medium
- Test organisms (species):
- other: Caenorhabditis elegans
- Details on test organisms:
- Strain: N2
Genotype: C. elegans wild type
Source: Caenorhabditis Genetic Centre; University of Minnesota; Minneapolis; MN 55455; USA.
Cultivation: C. elegans were cultivated according to ISO 10872. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Test temperature:
- 19.5-20.5 °C
- Nominal and measured concentrations:
- Test 1: 0, 313, 625, 1250, 2500, 5000 mg/l
Test 2: 0, 125, 250, 500, 1000, 2000, 4000 mg/l - Duration:
- 96 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 313 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- growth
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 250 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- growth
- Duration:
- 96 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 313 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- reproduction
- Key result
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 250 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- reproduction
- Details on results:
- A first test showed that strong effects of Syl on growth and reproduction already occurred at the lowest tested concentration of 313 mg/l (e.g. >50% inhibition of reproduction). Therefore, a second test was performed with lower concentration steps in order to get a proper dose-response.
Compared to the control, first significant inhibitory effect of Syl on nematode growth and reproduction could be observed at nominal concentrations of 313 mg/L in the first test (water test 1: p < 0.001; one-way ANOVA [df = 5; growth: F = 121.678; reproduction: 87.683], growth:
posthoc Dunnett: p < 0.001; reproduction: posthoc Games-Howell: p < 0.001) and at a nominal concentration of 500 mg/L in the second test (water test 2: p < 0.001; oneway ANOVA [df = 6; growth: F = 38.116; reproduction: 37.644], growth: posthoc Dunnett: p < 0.001; reproduction: posthoc Games-Howell: p < 0.001). For both toxicity endpoints, a NOEC of 250 mg/L could be calculated (water test 2: growth: posthoc Dunnett: p
= 1.000; reproduction: posthoc Games-Howell: p = 0.532).
If using data of both tests, proper dose-response curves could be established for growth and reproduction. Based on the logistic function that significantly fitted the dose-response curve to the observed toxicity data, an EC10 value was calculated as 215 mg/L for growth and EC10 and EC50 were calculated as 136 and 331 mg/L, respectively, for reproduction. NOEC and EC10 values matched quite nicely for both toxicity endpoints. %MDD could properly predict first significant effects of growth. For reproduction the mean %MDD predicted significant effects already at lower concentrations. However, variance of the reproduction was quite heterogenous between the different treatments (Levene’s test: p = 0.001) leading to a large range range of %MDD values: 7 – 31). - Validity criteria fulfilled:
- yes
- Conclusions:
- NOECs for growth and reproduction were both 250 mg/l.
- Executive summary:
The toxicity of the zeolite Sylosiv via spiked water, sediment and soil was tested with the nematode Caenorhabditis elegans, using the ISO guideline 10872. In spiked water, Syl inhibited growth and reproduction of C. elegans dose-dependently at concentrations ≥ 313 mg/L, with a NOEC at 250 mg/L.
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 21-day test on reproduction, growth and mortality; five concentrations plus control
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Type A Zeolite
- Analytical monitoring:
- yes
- Details on sampling:
- Actual test concentrations of zeolite were measured during all partial and full chronic studies with macroinvertebrates and fish by digesting the aluminosilicate to molybdate-reactive silica after APHA.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- 24 ± 12 h old
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
- Hardness:
- 120 mg/L
- pH:
- 7.3 ± 0.4
- Nominal and measured concentrations:
- control, 23.6, 36.8, 129.5, 264.3, 415.0 mg/l measured
- Reference substance (positive control):
- no
- Key result
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 130.8 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Basis for effect:
- reproduction
- Remarks:
- also growth, & survival
- Remarks on result:
- other: calculated form MATC according to Table R.10-1 of the Guidance on information requirements and chemical safety assessment chapter R.10
- Key result
- Duration:
- 21 d
- Dose descriptor:
- other: MATC
- Effect conc.:
- ca. 185 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Basis for effect:
- reproduction
- Remarks:
- also growth & survival
- Remarks on result:
- other: geometric mean of 129.5 and 264.3
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 214.6 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Basis for effect:
- reproduction
- Remarks on result:
- other: 95% confidence limits: 174.3- 256.2 mg/l
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 377.2 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Basis for effect:
- reproduction
- Remarks on result:
- other: 95 % confidence limits: 315.3-464.8 mg/l
- Details on results:
- The 21-day chronic exposure of the cladoceran, Daphnia magna, was run under continuously mixed conditions to maintain suspensions of zeolite. The results indicated that the compound was essentially nontoxic to this species, normally a highly sensitive indicator of adverse environmental conditions. No effects were observed on survival, growth, or percentage of days reproduction occurred during exposure to suspensions of zeolite less than 129.5 mg/L. The MATC was given as between 129.5 and 264.3 mg/l, with a geometric mean of c. 185 mg/l. According to Table R.10-1 of the Guidance on information requirements and chemical safety assessment chapter R.10 this value has to be divided by the square root of 2 to derive a NOEC, which is c. 130.8 mg/l in the present case.
Probit analyses of the data indicated 50% effect concentrations ranged from 211 mg/L for total young production to 377 mg/ for a 96-h LC50. It is likely that the negative effects on survival and reproduction seen at higher concentrations were due to physical effects of the compound on feeding and motility since these suspensions were extremely turbid. - Validity criteria fulfilled:
- not specified
- Conclusions:
- No effects were observed on survival, growth, or percentage of days reproduction occurred during exposure to suspensions of zeolite less than 129.5 mg/L.
The calculated NOEC is c. 130.8 mg/l. - Executive summary:
A 21-day full chronic test with Daphnia magna was conducted.
Referenceopen allclose all
Description of key information
No effects were observed on survival, growth, or percentage of days reproduction of daphnia magna occurred during exposure to suspensions of Type A Zeolite less than 129.5 mg/L. The MATC was given as between 129.5 and 264.3 mg/l, with a geometric mean of c. 185 mg/l. According to Table R.10-1 of the Guidance on information requirements and chemical safety assessment chapter R.10 this value was divided by the square root of 2 to derive a NOEC, which is c. 130.8 mg/l.
The lowest NOEC values observed for the reproduction of the nematod C. elegans were 250 mg/l.
No marine water species was tested.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- NOEC
- Effect concentration:
- ca. 130.8 mg/L
Additional information
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