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Diss Factsheets
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EC number: 203-564-8 | CAS number: 108-24-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
An Annex VII Column 2 adaptation applies since acetic anhydride is corrosive. In addition the weight of evidence indicates that acetic anhydride does not have sensitising potential.
There are no reports of skin sensitisation/allergic contact dermatitis to acetic anhydride in humans generally, or among those known to have been exposed to this chemical.
There is a lack of studies examining the skin sensitisation potential of acetic anhydride in well conducted guideline methods. Some evidence of acetic anhydride being associated skin reactions in guinea pigs was reported in 1940 (Jacobs, 1940; Jacobset al., 1940). However, these studies are of poor quality, and from data available it is not possible to distinguish between true allergic contact dermatitis and irritant reactions. The conclusion drawn is that acetic anhydride lacks the potential to induce skin sensitisation.
This conclusion is consistent with the fact that although, in principle, acetic anhydride will have some ability to associate with protein, this would be in the absence of protein cross-linking (HSE, 2002), and would result only in addition to the protein of a small acetyl leaving group. The available evidence indicates that acetic anhydride would not generate a hapten-protein complex capable of inducing an immune response and the acquisition of skin sensitisation.
Citations
Jacobs, JL (1940) Immediate Generalized Skin Reactions in Hypersensitive Guinea Pigs. Proc. Soc. Exptl. Biol. Med. V43 p641
Jacobs, JL et al. (1940) Immediate Reactions to anhydrides of immediate and erythema type. Proc. Soc. Exptl. Biol. Med. V43 p74 -77
UK HSE (2002) HSE EH 72/16 Acetic Anhydride : Risk assessment document. ISBN 0 7176 2364 5
Migrated from Short description of key information:
The weight of evidence indicates that acetic anhydride does not have sensitising potential.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
There is no evidence that exposure to acetic anhydride is associated with respiratory allergy
No data are available regarding the ability of acetic anhydride to induce in animals sensitisation of the respiratory tract, or respiratory allergy.
The inability of acetic anhydride to generate an immunogenic hapten-protein complex is consistent with the lack of respiratory allergic potential
Migrated from Short description of key information:
The weight of evidence indicates that acetic anhydride does not have sensitising potential.
Justification for classification or non-classification
The weight of evidence indicates that acetic anhydride does not have sensitising potential. No classification is warranted.
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