Registration Dossier
Registration Dossier
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EC number: 200-875-0 | CAS number: 75-50-3
Endpoint summary
Administrative data
Description of key information
Additional information
Regarding transport and distribution, information about soil adsorption of trimethylamine as well as a calculation for the Henry´s Law constant of the substance is available. Trimethylamine is not suspected to adsorb significantly to suspended solids and sediments due to the estimated Koc values of 6 (von Oepen, 1991) as well as values of 4 and 29 (Lyman, W.C., 1982 - Handbook of Chemical Property Estimation Methods; Pomona College Medicinal Project - Log P database, Swann et al., 1984, and The Arizona Data Base). A high mobility in soil is expected for the substance. For the uncharged form of trimethylamine a Koc of 7.32 (logKoc of 0.86) was calculated with the MCI method of computer program KOCWIN2.00 of EPISuite v4.11 (Chemservice S.A., 2018). The adsorption of trimethylamine (and other amines) by Montmorillonite and Kaolinite is consistent with control by electrostatic attraction and van der Waals forces. In clays and Flax Pont sediments the adsorption of amines can be a reversible process (Wang, X.C. and Lee, C., 1993).
At 25 °C a Henry´s Law Constant of 3.7 Pa m3/mol was calculated. However, the model does not consider the ionic form of the molecule at environmental conditions; hence, distribution into air may be overestimated (Chemservice S.A., 2018). A SRC recommended value of 0.000104 atm m3/mol (corresponding to 10.5 pa m3/mol) was additionally reported by Hine (1975). Based on a weight-of-evidence approach by the available data, the substance is assessed to slowly evaporate into the atmophere from the water surface. Distribution modelling was performed using the estimation tools Mackay (Level I) and the Fugacity Model (Level III; EPISuite v4.11). Over time the substance will preferentially distribute into the compartments water (91.5%) and air (8.5%). As the substance ionises at environmetally relevant pH, the distribution into water may still be underestimated.
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