Registration Dossier
Registration Dossier
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EC number: 202-626-1 | CAS number: 98-00-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Information from published review article
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Criteria for a recommended standard – occupational exposure to furfuryl alcohol.
- Author:
- US National Institute for Occupational Safety & Health
- Year:
- 1 979
- Bibliographic source:
- DHEW (NIOSH) Publication 79-133
- Reference Type:
- other: primary citation; company data
- Title:
- Physiological data on furfuryl alcohol Project 1011-B, Report No 2,Chicago
- Author:
- Woods LA & Seevers MH
- Year:
- 1 954
- Bibliographic source:
- The Quaker Oats Co, Chemicals Division, 15 pp (cited in NIOSH, 1979)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: guideline not specified
- Principles of method if other than guideline:
- LD50 assessment
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Furfuryl alcohol
- EC Number:
- 202-626-1
- EC Name:
- Furfuryl alcohol
- Cas Number:
- 98-00-0
- Molecular formula:
- C5H6O2
- IUPAC Name:
- (furan-2-yl)methanol
- Details on test material:
- 4 % and 2% aqueous solutions
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 225-275 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- gastric intubation
- Doses:
- 2% and 4% aqueous solution
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 149 mg/kg bw
- Based on:
- other: dosing with 4% aqueous solution
- 95% CL:
- >= 142 - <= 156
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 451 mg/kg bw
- Based on:
- other: dosing with 2% aqueous solution
- 95% CL:
- >= 444 - <= 463
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 132 mg/kg bw
- Remarks on result:
- other: Overall conclusion of author, but no data to substantiate this value
- Sex:
- male
- Dose descriptor:
- other: signs of toxicity
- Remarks on result:
- other: only signs reported were terminal convulsion
Applicant's summary and conclusion
- Conclusions:
- In rats, the oral LD50 was reported to be in the range of 132 - 451 mg/kg
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