Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 233-046-7 | CAS number: 10025-87-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Summary of non-standard study; adequate for the purposes of classification
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Investigation of the irritant effects of a transient dermal exposure and assessment of the efficacy of decontamination.
- GLP compliance:
- not specified
- Remarks:
- : summary report only
Test material
- Reference substance name:
- Phosphoryl trichloride
- EC Number:
- 233-046-7
- EC Name:
- Phosphoryl trichloride
- Cas Number:
- 10025-87-3
- Molecular formula:
- Cl3OP
- IUPAC Name:
- phosphoroyl trichloride
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 60 seconds
- Observation period:
- Not reported
- Number of animals:
- Not reported
Results and discussion
In vivo
Results
- Irritation parameter:
- other: details are not reported
- Reversibility:
- no data
- Remarks on result:
- other: signs of severe skin irritation or corrosion were noted
- Other effects:
- Depending on the decontamination method, the substance is reported to be either a severe irritant or corrosive to skin.
Any other information on results incl. tables
Depending on the decontamination method, the substance is reported to be either a severe irritant or corrosive to skin.
Applicant's summary and conclusion
- Interpretation of results:
- other: corrosive
- Conclusions:
- Application of phosphoryl trichloride to skin resulted in severe irritation or corrosive effects.
- Executive summary:
100 µl of phosphoryl trichloride applied to shaved rabbit skin for 60 seconds resulted in severe skin irritation or corrosive effects.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
