Registration Dossier
Registration Dossier
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EC number: 205-391-3 | CAS number: 140-01-2
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The 28-day NOEC for reproduction in the crimson-spotted rainbowfish (Melanotaenia fluviatilis) was 100 mg/L DTPA (free acid), which is equivalent to 127 mg/L pentasodium DTPA.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 127 mg/L
Additional information
One chronic study for fish was available for DTPA (free acid). This study was well documented and met generally accepted scientific principles, and thus, was considered acceptable for assessment. In this study, adult male and female crimson-spotted rainbowfish (Melanotaenia fluviatilis) were exposed to DTPA (free acid) in a static-renewal system for a period of 28 days. Upon contact with water, pentasodium DTPA is expected to dissociate, thus, is it considered essentially equivalent to the free acid form of DTPA in aquatic environments. The endpoints that were measured in this study included reproduction, liver-somatic index, gonadal-somatic index, condition factor and EROD activity. There were no effects of parental DTPA (free acid) exposure on apical endpoints, such as reproduction or condition factor, at the highest test concentration of 100 mg/L DTPA (free acid), which, following stoichiometric conversion, is equivalent to 127 mg/L pentasodium DTPA.
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