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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 210-323-0 | CAS number: 612-83-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- year of publication: 1974
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: insufficiently documented literature data, details on study design and results are missing
Data source
Reference
- Reference Type:
- publication
- Title:
- Industrial experience with 3,3'-dichlorobenzidine. An epidemiological study of a chemical manufacturing plant.
- Author:
- Gerarde HW, Gerarde DF
- Year:
- 1 974
- Bibliographic source:
- J. Occup. Med. 16: 322-344
- Report date:
- 1974
Materials and methods
- Principles of method if other than guideline:
- subacute inhalative toxicity test
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 3,3'-dichlorobenzidine
- EC Number:
- 202-109-0
- EC Name:
- 3,3'-dichlorobenzidine
- Cas Number:
- 91-94-1
- IUPAC Name:
- 3,3'-dichlorobiphenyl-4,4'-diamine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 2 hours/day for seven days
- Frequency of treatment:
- 2 hours/day for seven days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
15 L chamber into which 355 mg were blown during the 2h period
Basis:
- No. of animals per sex per dose:
- 10 males
- Control animals:
- no
- Details on study design:
- Animals were exposed in a 15 liter chamber into which 355 mg of the test material were blown.
- Positive control:
- no
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
No adverse effects were detected during the 7 day exposure period. The animals continued to gain weight during the exposure duration.
Applicant's summary and conclusion
- Executive summary:
When exposing 10 rats 2 h/day for seven days to 355 mg of test material blown into a 15 l chamber during the 2 h period animals continue to gain weight and were not uncomfortable. No advers effects could be detected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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