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Diss Factsheets
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EC number: 203-311-1 | CAS number: 105-58-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- sub-chronic toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Description of the method often not very clear. The experimental results are doubtful, because the mortality rate in the control group was rather high.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Skin Initiating Action and Lung Carcinogenesis by Derivatives of Urethane (Ethyl Carbamate) and Related Compounds
- Author:
- Berenblum, I. et al.
- Year:
- 1 959
- Bibliographic source:
- Biochemical Pharmacology 2, 168-176
- Reference Type:
- review article or handbook
- Title:
- No information
- Author:
- BG Chemie
- Year:
- 1 994
- Bibliographic source:
- Toxicological Evaluations 7: Potential Health Hazards of Existing Chemicals, 7.7 Carcinogenicity, p.40, 1994, BG Chemie, Springer Verlag, ISBN 3-540-57300-3
Materials and methods
- Principles of method if other than guideline:
- Method: other: subchronic intraperiteoneal injection
- GLP compliance:
- no
Test material
- Reference substance name:
- Diethyl carbonate
- EC Number:
- 203-311-1
- EC Name:
- Diethyl carbonate
- Cas Number:
- 105-58-8
- Molecular formula:
- C5H10O3
- IUPAC Name:
- diethyl carbonate
- Details on test material:
- Name of the test substance as stated in the publication: diethyl carbonate;
Purchased from Eastman Kodak, Rochester, USA
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: saline
- Duration of treatment / exposure:
- 40 weeks
- Frequency of treatment:
- twice per week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
11.4 mg, nominal in saline
- No. of animals per sex per dose:
- 30 (total, no information on sex distribution)
- Control animals:
- other: yes, croton oil
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
After 20 weeks of treatment 4/30 animals showed skin tumours. The corresponding control group showed in 3 cases of the 45 surviving animals skin tumours (total number of control animals 46).
At the end of the experiment (40 weeks) 12/30 animals showed skin tumours. Analysis of the lungs showed no corresponding carcinogenesis. In the control group 11/40 animals had skin tumours and 2/42 had lung tumours.
Applicant's summary and conclusion
- Conclusions:
- The test substance diethylcarbonate was intraperitoneally injected in Swiss mice (male/female) for 40 weeks. 40 % of the treated animals showed skin tumours. No treated animal beared any lung tumours.
In a review of the BG Chemie the publication of Berenblum et al. 1959 was also discussed and the author mentioned that this study is "unsuitable for use in evaluation of the possible carcinogenic potential of carbonic acid diethyl ester" because of the small numbers of animals involved and the sometimes low survival rate.
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