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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 203-311-1 | CAS number: 105-58-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Reliable review from BG Chemie Germany (Professional Association Chemistry in Germany) about the toxicology of diethyl carbonate. The BG Chemie is the central institution to facilitate workplace safety in the chemical industry in Germany. It is referred to the original data source which is a publication.
- Principles of method if other than guideline:
- No information if data generation was in accordance with an official guideline.
- GLP compliance:
- no
- Conclusions:
- Interpretation of results (migrated information): low bioaccumulation potential based on study results
As an ester diethyl carbonate may be metabolised to ethanol and CO2 in the body, in particular in the intestine or in the kidneys. This assumption may be supported by the results of Lang et al. who found the generation of CO2 when the substance was in contact with homogenates (and therefore enzymes) of bovine kidney and intestinal membrane. Carbon dioxide is a natural metabolite in the human body. Ethanol has a known toxicity profile and is also metabolised without accumulation in the body. If this metabolism takes place the risks associated with it would be limited.
Reference
As stated in the review of BG Chemie (1994):
7. Experimental results
7.1 Toxicokinetics and metabolism
Enzymatic cleavage of carbonic acid diethyl ester occurred on incubation with homogenates of bovine kidney or mucous membrane from the small intestine. The increase in pressure caused by liberated CO2 was measured manometrically in a Warburg apparatus (Lang et al., 1966).
Description of key information
Lang et al. (1966) found the generation of CO2 when diethyl carbonate was in contact with intestinal enzymes.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
As an ester diethyl carbonate may be metabolised to ethanol and CO2 in the body, in particular in the intestine or in the kidneys. This assumption may be supported by the results of Lang et al. who found the generation of CO2 when the substance was in contact with homogenates (and therefore enzymes) of bovine kidney and intestinal membrane. Carbon dioxide is a natural metabolite in the human body. Ethanol has a known toxicity profile and is also metabolised without accumulation in the body. If this metabolism takes place the risks associated with it would be limited.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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