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EC number: 204-399-4
CAS number: 120-47-8
Based on all available data on ethylparaben and structural similar
substances, ethylparaben is considered to have no carcinogenic potential.
There are no data available on carcinogenicity of ethylparaben.
Ethylparaben was not genotoxic in in vitro mutagenicity studies in
bacteria (Ames Test) (Donath, 2012, Ishidate et al., 1984). Moreover,
there are two subchronic repeated dose toxicity studies available on
ethylparaben which gave no evidence of preneoplastic or neoplastic
lesions. In addition, methylparaben was tested in several non-guideline
studies, investigating carcinogenicity after subcutaneous and
intravenous application in rats and mice. There were no preneoplastic or
neoplastic lesions observed. Methylparaben was also tested in Ames tests
and in two in vivo tests (chromosome aberration test and a
dominant-lethal test (Litton Bionetics Inc, 1974)) which were all found
negative for genotoxicity. Several chronic repeated dose toxicity
studies on methylparaben gave no evidence of preneoplastic or neoplastic
lesions. Propylparaben was not genotoxic in several Ames tests and a
HPRT test (Brusick, 1975; McCann et al., 1975; Wollny, 2012). Based on
all available data on ethylparaben and structural similar substances,
ethylparaben is considered to have no carcinogenic potential.
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