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Toxicological information

Basic toxicokinetics

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basic toxicokinetics, other
Type of information:
not specified
Publication supporting read-across and providing toxicokinetic data
Adequacy of study:
supporting study

Data source

Reference Type:
Application of grouping and read‑across for the evaluation of parabens of different chain lengths with a particular focus on endocrine properties
Susann Fayyaz, Reinhard Kreiling, Ursula G. Sauer

Materials and methods

Results and discussion

Applicant's summary and conclusion

Executive summary:

The in vivo toxicokinetic screening studies consistently showed that Methyl, ethyl and propyl paraben were taken up systemically very rapidly after oral gavage administration to rats and that they were eliminated very rapidly from the bloodstream within one hour after administration. Also, for all test items, the major metabolite p-hydroxybenzoic acid was cleared rapidly from the blood stream within 4–8 h. P-hydroxybenzoic acid does not exhibit systemic toxicity or DART, and it is also not endocrine active.