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Diss Factsheets
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EC number: 210-036-0 | CAS number: 603-35-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable test method without detailed documentation; reliable experimental data
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 975
Materials and methods
- Principles of method if other than guideline:
- - Principle of test: 6 male rats were whole body exposed to an aerosol of the test substance for 4 hours. Therefore, the test stubstance was molten to liquify, nebulized under a stream of dry nitrogen and diluted with 20 % oxygen. The animals were observed 7 days for mortality and syptoms of acute intoxication. Animals were examiened for gross pathological and histopathological changes.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Triphenylphosphine
- EC Number:
- 210-036-0
- EC Name:
- Triphenylphosphine
- Cas Number:
- 603-35-0
- Molecular formula:
- C18H15P
- IUPAC Name:
- triphenylphosphine
- Test material form:
- solid: crystalline
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Chr-CD (Charles River-CD)
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charales River.
- Age at study initiation: adult.
- Weight at study initiation: 250-275 grams.
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: nitrogen stream diluted with 20 % oxygen
- Remark on MMAD/GSD:
- particel size distribution not specified
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: boroilicate glass bell jars.
- Exposure chamber volume: 18 liter.
- System of generating particulates/aerosols: The test substance was nmelted in a glass flask and the molten material maintained at 90-115°C under dry, prepurified nitrogen . It was nebulized with a stainless steel nebulizer. Immediately prior
to entering the exposure chamber, the nitrogen-diluted stream of each material under study was again diluted with cylinder oxygen to an oxygen content of 20% (v/v) .
TEST ATMOSPHERE
- Brief description of analytical method used: Atmospheric samples were collected in an evacuated gas-sampling bulb of known volume. The sample was quantitatively transferred from the bulb with absolute alcohol and the washings diluted to a known volume. To calculate test substance concentrations, the O.D. of this solution was determined at 260 nm. The lower limit of quantitative detection by this method was 1.9 moles (500 ug) of test substance. The standard curve was linear for the ranges of concentrations used. Chamber atmospheres were analyzed at least hourly. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- not specified
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: not specified
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, gross pathology, histopathology
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 12.5 mg/L air
- 95% CL:
- >= 8.6 - <= 18.2
- Exp. duration:
- 4 h
- Remarks on result:
- other: 32.6 - 69.6 μmol/l
- Mortality:
- No individual data on mortality available.
- Clinical signs:
- other: Clinical signs were typical of respiratory irritation: red ears, salivation, lacrimation, facepawing and dyspnea.
- Gross pathology:
- No macroscopic or histopathological findings.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LC50 = 12.5 mg/L
- Executive summary:
Six male rats were whole body exposed to an aerosol of the test substance for 4 hours. Therefore, the test stubstance was molten to liquify, nebulized under a stream of dry nitrogen and diluted with 20 % oxygen prior to entering the exposure chamber. The animals were observed 7 days for mortality and syptoms of acute intoxication. Animals were examiened for gross pathological and histopathological changes. The animals showed clinical signs typical of respiratory irritation: red ears, salivation, lacrimation, facepawing and dyspnea. No macroscopic or histopathological effects were observed. No individual data on mortality were reported, however, a LC50 of 12.5 mg/L was stated.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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