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EC number: 210-036-0 | CAS number: 603-35-0
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Not readily biodegradable (according to OECD criteria).
Key value for chemical safety assessment
- Biodegradation in water:
- not biodegradable
- Type of water:
- freshwater
Additional information
QSAR-disclaimer
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met. According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided. For the assessment of TPP (CAS 603-35-0) (Q)SAR results were additionally used for biodegradation. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.
Assessment
No experimental data are available for the assessment of TPP (CAS 603-35-0). Therefore, a read-across approach was performed with the structurally similar substance TPPO (CAS 791-28-6). TPPO was assessed in a Manometric Respirometry Test performed according to OECD 301F (BASF AG, 1987). In this study, domestic activated sludge was used as inoculum. Biodegradation of TPPO was determined to be <10 % (O2 consumption) after 28 days. In addition, the available experimental biodegradation data was supported by (Q)SAR calculations for TPP (CAS 603-35-0): - The model CATALOGIC 301C v12.17 (OASIS Catalogic v5.15.2.14) calculated biodegradation of TPP to be 6% after 28 days, based on CO2-Evolution. Due to 25% unknown fragments in the training set, the substance was not entirely within the model’s applicability domain. Based on all available data, the substance is considered to be not readily biodegradable (according to OECD criteria).
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