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EC number: 203-699-2 | CAS number: 109-73-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Study initiation date: 24 June 2009 Study completion date: 12 October 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- adopted on 27th July 1995
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes
- Type of method:
- flask method
- Water solubility:
- >= 50 other: % (w/w)
- Temp.:
- 20 °C
- pH:
- 13.8
- Key result
- Water solubility:
- >= 424 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 5 other: g of test item added to 5 mL of water
- Incubation duration:
- 69 h
- Temp.:
- 20 °C
- pH:
- 13.8
- Remarks on result:
- other: miscible at least up to a ratio of 1:1 (by weight)
- Details on results:
- The water solubility of the test item was determined according to OECD guideline no. 105 [adopted
on 27 July 1995] and EU test method A.6 [Directive 92/69/EEC, Official Journal L 383 A 1992] with
the modified flask method.
The test item is miscible in a 1 : 1 ratio mixture (w/w) with water (at 20°C). - Conclusions:
- The test item is miscible at least up to a ratio of 1 : 1 (w/w) with water (at 20°C and pH 13.8). This corresponds to a water solubility of >= 424 g/L.
- Executive summary:
The water solubility of the test item was determined compliant with GLP according to OECD guideline no. 105 [adopted on 27 July 1995] and EU test method A.6 [Directive 92/69/EEC, Official Journal L 383 A 1992] with the modified flask method. The test item is miscible at least up to a ratio of 1 : 1 (w/w) with water (at 20°C and pH 13.8). This corresponds to a water solubility of >= 424 g/L.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: detailed representation
- GLP compliance:
- no
- Type of method:
- flask method
- Key result
- Water solubility:
- <= 736.9 g/L
- Conc. based on:
- test mat.
- Remarks:
- As a limit value for water solubility, the density of n-butylamine at 20°C is given
- Temp.:
- 20 °C
- Remarks on result:
- completely miscible
- Details on results:
- Mutual solubility determinations of water and n-butylamine confirmed miscibility with water in all proportions up to the boiling point of the amine (0 - 78°C).
- Conclusions:
- Mutual binary solubilities were experimentally meassured for aliphatic amines including n-butylamine. All amines up to C4 were found to be miscible with water in all proportions up to the boiling point of the amine (0 - 78°C for n-butylamine).
Referenceopen allclose all
The concentration of the test item in both 1:1 (weight) mixtures of test item and water were determined by carbon analysis, with the following results:
Sample |
Amount of |
Added volume of |
Analysed carbon |
Concentration of |
pH value2) |
1 |
5.012 |
5 |
32.4 |
50.3 |
13.79 |
2 |
5.007 |
5 |
32.3 |
50.2 |
13.79 |
1) calculated from the carbon concentration of the sample solutions and the carbon content of the pure test item (64.4 %)
2) The purified water used for the tests had a pH value of 6.46.
Description of key information
Water solubility (OECD 105, flask method): >= 424 g/L at 20 °C and pH 13.8;
Miscibility with water in all proportions up to the boiling point of the amine was confirmed by Stephenson (1993). Therefore, as key value below the densitiy of n-butylamine is given as the upper limit for solubility in water.
Key value for chemical safety assessment
- Water solubility:
- 736.9 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test item was determined according to OECD guideline no. 105 [adopted on 27 July 1995] and EU test method A.6 [Directive 92/69/EEC, Official Journal L 383 A 1992] with the modified flask method. The test item is miscible at least up to a ratio of 1 : 1 (w/w) with water (at 20°C and pH 13.8). This corresponds to a water solubility of >= 424 g/L at pH 13.8 and 20 °C.
No higher ratios n-butylamin : water have been tested in this study. Based on a pKa of 10.8, at a pH of 13.8 the majority of molecules will be neutral. Thus, at environmentally relevant pH water solubility will even be larger.
Miscibility in ratios n-butylamine : water higher than 1:1 is confirmed by results from the supporting study (Stephenson, 1993). Mutual binary solubilities were experimentally meassured for aliphatic amines including n-butylamine. All amines up to C4 were found to be miscible with water in all proportions up to the boiling point of the amine (0 - 78°C for n-butylamine). Accordingly, as an upper boundary for water solubility the density of n-butylamine at 20 °C could be used, i.e. 736.9 g/L.
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