Alcohols, C12-15-branched and linear

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Study period:

1980

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline study with acceptable restrictions, no monitoring of saturated atmosphere.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1980

Report date:

1980

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Principles of method if other than guideline:

Method: other: in house protocol

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Alcohols, C12-16

EC Number:

272-490-6

EC Name:

Alcohols, C12-16

Cas Number:

68855-56-1

IUPAC Name:

tetradecan-1-ol

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Shell Toxicology Laboratory (Tunstall) Breeding Unit,  Sittingbourne, Kent, UK
- Age at study initiation: 8 weeks approx.
- Weight at study initiation: not reported 
- Housing: after exposure the animals were individually housed in hanging polypropylene cages with stainless steel wire mesh floor and top
- Diet: ad libitum, except during exposure
- Water: ad libitum, except during exposure



ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/-2
- Humidity (%): 55 +/- 5
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

whole body

Vehicle:

other: Condensation mist atmosphere

Details on inhalation exposure:

- Concentrations: saturated atmosphere (no monitoring reported)
- Particle size: not reported
- Type or preparation of particles: condensation mist

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

4 h

Concentrations:

saturated atmosphere

No. of animals per sex per dose:

5M, 5F

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical signs observed throughout exposure and daily thereafter throughout an observation period of at least 14 days. Initial,  7 and 14 day bodyweights were recorded.
- Necropsy of survivors performed: no

Results and discussion

Effect levels

Effect level:

> 10 000 000 000 mg/L air

Remarks on result:

other: = LC50 >saturated vapour concentration

Mortality:

All animals survived the 4 hour exposure and subsequent  observation period.

Clinical signs:

other: There were no signs of toxicity during or after exposure.

Body weight:

Not reported.

Gross pathology:

Not carried out.

Other findings:

POTENTIAL TARGET ORGANS: None identified.
SEX-SPECIFIC DIFFERENCES: None reported.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The 4 hour rat inhalational LC50 for Dobanol 25 is >saturated vapour concentration. There were no signs of toxicity during exposure or the subsequent observation period..