Registration Dossier
Registration Dossier
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EC number: 201-152-2 | CAS number: 78-87-5
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: standard NTP methodology
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,2-dichloropropane
- EC Number:
- 201-152-2
- EC Name:
- 1,2-dichloropropane
- Cas Number:
- 78-87-5
- Molecular formula:
- C3H6Cl2
- IUPAC Name:
- 1,2-dichloropropane
- Details on test material:
- Name. 1,2-dichloropropane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Duration of treatment / exposure:
- 14 days
- Frequency of treatment:
- Consecutive days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 125, 250, 500, 1000 or 2000 mg/kg bw/d
Basis:
- No. of animals per sex per dose:
- Groups of 5 male and 5 female
- Control animals:
- yes, concurrent vehicle
Results and discussion
Effect levels
open allclose all
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- 500 mg/kg bw/day (nominal)
- Sex:
- male/female
- Basis for effect level:
- mortality
- Key result
- Dose descriptor:
- LOAEL
- Effect level:
- 1 000 mg/kg bw/day (nominal)
- Sex:
- male/female
- Basis for effect level:
- mortality
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
GC analysis of the dosing solutions demonstrated that the achieved concentration was 95 - 100% of target. All rats given 2000 mg/kg bw died during the study, along with a single male from the 125 mg/kg bw/d group. Final mean body weight was decreased 14-15% in animals given 1000 mg/kg bw/d relative to the controls. The renal medullae were red in 4/5 males and 5/5 females given 2000 mg/kg bw/d but not in rats from the lower treatment groups.
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of the study, the sub-acute NOEL for PDC in male and female rats was 500 mg/kg bw/d.
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