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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2003
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
publication
Title:
OECD SIDS 1,2-DICHLOROPROPANE
Author:
OECD SIDS
Year:
2003
Bibliographic source:
UNEP PUBLICATIONS
Report date:
2003

Materials and methods

Type of study / information:
Excretion
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-dichloropropane
EC Number:
201-152-2
EC Name:
1,2-dichloropropane
Cas Number:
78-87-5
Molecular formula:
C3H6Cl2
IUPAC Name:
1,2-dichloropropane
Details on test material:
Name. 1,2-dichloropropane

Results and discussion

Applicant's summary and conclusion

Conclusions:
Urine and feces of F344 rats (4 animals/sex/concentration) were collected for 48 hours after inhalational exposure (head only) for 6 hours to 24, 235 and 470 mg [14C]1,2-dichloropropane/m3. 55 - 65 % of the recovered radioactivity was detected in urine and 6.3 - 9.7 % was detected in feces; 16 - 23 % of the radioactivity was exhaled as CO2.