Registration Dossier
Registration Dossier
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EC number: 232-234-6 | CAS number: 7790-94-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary literature.
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Toxicological evaluations 14
- Author:
- BG Chemie
- Year:
- 1 995
- Bibliographic source:
- Potential Health Hazards of Exisiting Chemicals.
- Reference Type:
- publication
- Title:
- Zur Bewertung der akuten Toxizitaet einer leichthydrolysierbaren Verbindung der Chlrosulfonsaeure (Schwefelsaeurechlorid).
- Author:
- Mamleeva NK, and Bakhtizina GZ
- Year:
- 1 976
- Bibliographic source:
- Tr Mosk NII Gigieny 9, 110-113.
- Reference Type:
- review article or handbook
- Title:
- Chlorosulfonic Acid
- Author:
- HSDB
- Year:
- 2 010
- Bibliographic source:
- National Library of Medicine (NLM, http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB)
Materials and methods
- Principles of method if other than guideline:
- The acute inhalation toxicity (LC50) of chlorosulphuric acid was studied in white rats. Rats were exposed once for 4 hours.
- GLP compliance:
- no
- Remarks:
- GLP was not mandatory at the time of the study.
- Test type:
- standard acute method
Test material
- Reference substance name:
- Chlorosulphuric acid
- EC Number:
- 232-234-6
- EC Name:
- Chlorosulphuric acid
- Cas Number:
- 7790-94-5
- Molecular formula:
- ClHO3S
- IUPAC Name:
- sulfurochloridic acid
- Details on test material:
- - Name of test material (as cited in study report): chlorosulfonic acid.
- Analytical purity: not reported.
Constituent 1
Test animals
- Species:
- rat
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Details on inhalation exposure:
- The study was repeated on several occasions because of possible hydrolysis of the substance in the inhalation chamber. The air was dried prior to entering to the chamber, but a persistent slight mist could still be observed.
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Concentrations:
- 16.0-92.4 mg/m³
- No. of animals per sex per dose:
- no data.
- Control animals:
- other: not necessary
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 38.5 mg/m³ air
- Exp. duration:
- 4
- Clinical signs:
- other: Clinical symptoms included severe irritation of the respiratory tract and eyes, a staggering gait, staining of the coat and clonic spasm.
- Gross pathology:
- Post-mortem examinations revealed hyperaemia of the lung and the liver and, in animals exposed to concentrations greater than the LC50, pulmonary oedema.
- Other findings:
- - Organ weights: the relative weights of the liver and lungs were increased in the rats and the relative spleen weights were decreased.
- Histopathology: histological examination revealed congestion of the internal organs, severe irritation of the tracheobronchial system and hyperaemia of the brain and meninges, with perivascular and pericellular oedema and swelling of the ganglion cells. Focal haemorrhages of the myocardium, with swelling and necrobiosis of individual myofibrils, were observed. In the liver, fatty degeneration of the hepatocytes, necrobiotic foci and structural breakdown of the liver canals were found. The kidneys showed effects suggestive of toxic nephrosis.
Applicant's summary and conclusion
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