Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 208-901-2 | CAS number: 546-46-3
Carcinogenicity
Administrative data
Description of key information
The data from zinc and citric acid will be used to derived data for trizinc dicitrate
Zinc
(45-53 wk drinking water study) no treatment related tumours mice (Walters and Roe, 1965, cited in the Zinc metal RAR, 2008).
Citric acid
No studies available, however long history of human exposure provides evidence for non-carcinogenicity of citric acid.
Key value for chemical safety assessment
Justification for classification or non-classification
Additional information
The effect of trizinc dicitrate is not expected to differ significantly from the effects of exposure to the zinc ions and citric acid separately once absorbed. Therefore, the assessment of this substance will be based on both citric acid and zinc respectively.
A limited carcinogenicity study where zinc sulphate was administered to mice in drinking water for 45 – 53 weeks, provided no indication of treatment related tumours (Walters and Roe, 1965, cited in the Zinc metal RAR, 2008).
Citric acid
There are no specific carcinogenicity studies with citric acid, however a long history of human exposure together with the absence of any treatment related effects in repeated dose studies mean that it is unlikely that citric acid would be carcinogenic.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
