Registration Dossier
Registration Dossier
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EC number: 208-901-2 | CAS number: 546-46-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Study period:
- 1996
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The result was obtained from a collection of reliable data which has been subject to peer-review and in which the original sources are traceable. This is a read across from Zinc distearate.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Final report of the safety assessment of lithium stearate, aluminium distearate, aluminium stearate, aluminium tristearate, ammonium stearate, calcium stearate, magnesium stearate, potassium stearate, sodium stearate, and zinc distearate.
- Author:
- Cosmetic Ingredient Review
- Year:
- 1 982
- Bibliographic source:
- J. Am. Coll. Toxicol. 1, 143-177. [as reported in the zinc distearate RAR 2008]
- Reference Type:
- secondary source
- Title:
- Zinc distearate RAR (2008). Risk Assessment Report zinc distearate (CAS 557-05-1) . Final Report, May 2008. European union risk assessment report for zinc distearate, volume 44.
- Author:
- ZINC RAR
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Zinc distearate
- EC Number:
- 209-151-9
- EC Name:
- Zinc distearate
- Cas Number:
- 557-05-1
- Molecular formula:
- C18H36O2.1/2Zn
- IUPAC Name:
- zinc dioctadecanoate
- Details on test material:
- - Name of test material : zinc distearate
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Albino
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- 1 h
- Concentrations:
- 200 mg/l
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 200 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Mortality:
- 1/10 rats died during 2-wk. observation period. Material was considered non toxic by investigators.
- Clinical signs:
- other: No information
- Body weight:
- No information
- Gross pathology:
- No information
Any other information on results incl. tables
1/10 rats died within the 14 day observation period.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance Zinc distearate is not toxic by inhalation route
- Executive summary:
The LC50 value of zinc distearate to rat is >200 mg/L air. The report was lacking in detail. The result is a read accross from zinc distearate (CAS 557-05-1).
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