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EC number: 203-047-7 | CAS number: 102-69-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented report which meets basic scientific principles (72 hour reading point is missing).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Method: BASF-Test: 50 µL of the test substance were applied to the conjunctival sac of one eye in 2 animals. The animals were observed after 10 min, 1 and 3 h on the day of treatment and up to 8 days afterwards. Findings were recorded daily. The eyes were not washed out after 24 hours as specified in OECD Guideline 405.
- GLP compliance:
- no
Test material
- Reference substance name:
- Tripropylamine
- EC Number:
- 203-047-7
- EC Name:
- Tripropylamine
- Cas Number:
- 102-69-2
- Molecular formula:
- C9H21N
- IUPAC Name:
- tripropylamine
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Tri-n-propylamin
- Physical state: liquid
- Analytical purity: >= 98 %
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.38 and 2.49 kg
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The adjacent eye served as control and was treated with 0.9 % NaCl (saline).
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 50 µL - Duration of treatment / exposure:
- single application
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no
A first test was done with 2 animals. In this test, both animals displayed erythema of similar severity and thus, similar scoring, in the control (0.9% NaCl) eye and the eye treated with the test item. Therefore, the test was repeated with a further 2 animals. In this test, the control eyes were as expected, i.e., without any findings, and thus, this test was considered suitable for assessment of the irritant potential of the test item. The results provided below refer to this test.
SCORING SYSTEM: The findings were re-evaluated according to the Draize scoring system, as recommended by the OECD.
TOOL USED TO ASSESS SCORE: fluorescein
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24, 48 hours
- Score:
- 0.75
- Max. score:
- 3
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: 72 h reading is missing
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility: not applicable
- Remarks on result:
- other: 72 h reading is missing
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48 hours
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: reversibility: not applicable
- Remarks on result:
- other: 72 h reading is missing
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24, 48 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility: not applicable
- Remarks on result:
- other: 72 h reading is missing
- Other effects:
- After 10 min at one animal eye secretion was noted.
Any other information on results incl. tables
Findings (animal 1):
Time |
Erythema |
Chemosis |
Corneal Opacity |
Iritis |
1h |
1 |
0 |
0 |
0 |
24h |
1 |
0 |
0 |
0 |
48h |
0 |
0 |
0 |
0 |
72h |
- |
- |
- |
- |
8d |
0 |
0 |
0 |
0 |
Findings (animal 2):
Time |
Erythema |
Chemosis |
Corneal Opacity |
Iritis |
1h |
1 |
0 |
0 |
0 |
24h |
1 |
0 |
0 |
0 |
48h |
1 |
0 |
0 |
0 |
72h |
- |
- |
- |
- |
8d |
0 |
0 |
0 |
0 |
Mean values over 24h and 48h (72h reading is missing):
Animal 1: Opacity: 0; Chemosis: 0; Erythema: 0.5
Animal 2: Opacity: 0; Chemosis: 0; Erythema: 1
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Mean conjunctivae score for both animals at 24-h and 48-h reading time points is 0.75. The erythema was fully reversible within 8 days. For cornea and iris, all scores were 0.0 at all reading time points. According to this study result, tripropylamine is likely not irritating to eyes.
- Executive summary:
The eye irritation potential of tripropylamine was determined in a test conducted to an internal BASF method. 50 µL of the test substance were applied to the conjunctival sac of one eye in 2 animals (Vienna White rabbits). The animals were observed after 10 min, 1 and 3 h on the day of treatment and up to 8 days afterwards. Findings were recorded daily. The eyes were not washed out after 24 hours as specified in OECD Guideline 405. The mean conjunctivae scores for erythema were 0.5 and 1.0 in animal 1 and in animal 2 after 24 -h and 48 -h reading points, respectively (72 -h reading is missing). The mean conjunctivae score for both animals at 24 -h and 48 -h is 0.75. The erythema was fully reversible within 8 days. For cornea and iris, all scores were 0.0 at all reading time points. According to this study result, tripropylamine is likely not irritating to eyes.
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