Registration Dossier
Registration Dossier
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EC number: 218-915-0 | CAS number: 2280-49-1
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
The bioaccumulation factor of N-phenyl-N-[(trichloromethyl)thio]benzenesulfonamide was estimated to be 586 L/kg ww using the BCFBAF model included in the EPI-Suite Programm concluding that the substance has a moderate potential to bioaccumulate in biota.
Key value for chemical safety assessment
- BCF (aquatic species):
- 586 L/kg ww
Additional information
The bioaccumulation factor of N-phenyl-N-[(trichloromethyl)thio]benzenesulfonamide was estimated to be 586 L/kg ww using the BCFBAF model included in the EPI-Suite Programm concluding that the substance has a moderate potential to bioaccumulate in biota.
PBT-Assessment: The partition coefficient of the substance is experimentally determined to be 4.7 which is slightly above the B criterion of <= 4.5. However, BCF QSAR estimation (= 586) indicated that bioaccumulation is far below the criterion of 2000 for B as well as 5000 for vB. Furthermore, it should be considered that the substance has a very low water solubility of 50 µg/L and readily hydrolysis with the low amounts being dissolved in water. In conclusion, the substance is not assumed to fulfill the B criterion and in particular not to fulfill the vB criterion. Need for a new study on bioaccumulation behaviour: With respect to the need of a study on bioaccumulation it should be considered that the substance does not fulfill the T criterion. Therefore, independent on a bioaccumulation study result the substance will not be rated as PBT. There is also no equivalent concern based on classification or other available data. There is the possibility to rate the substance as vPvB as it fulfills the P and vP criterion. However, taking into account the details above the substance could as a worst case be expected to fulfill the B criterion but it is very unlikely that it fulfills the vB criterion. So, the substance will not be rated as PBT or as vPvB and, consequently, a vertebrate study to investigate bioaccumulation behaviour seems scientifically not to be justified. The available data are expected to be sufficient to allow the evaluation of the bioaccumulation behaviour of the substance.
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