Registration Dossier
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EC number: 600-033-6 | CAS number: 1001416-18-7
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 April - 25 July, 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study has been performed according to OECD and/or EC guidelines and according to GLP principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- 1-Propanone, 2-hydroxy-2-methyl-, 1-(4-C10-13-alkylphenyl) derivs.
- Cas Number:
- 1001416-18-7
- Molecular formula:
- Not applicable - UVCB
- IUPAC Name:
- 1-Propanone, 2-hydroxy-2-methyl-, 1-(4-C10-13-alkylphenyl) derivs.
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- 0.764 - 1.53 mg/L
- Temp.:
- 20 °C
- pH:
- ca. 7.8
- Details on results:
- The maximum difference (MD) of the mean concentrations determined in the 24, 48 and 72 hour test samples was > 15%. This may be explained by the variation in data for each individual sampling point. Despite the fact that the sample solutions were visually clear after the alternative sample treatment procedure, undissolved test substance may still be present. Since centrifugation was not successful, this treatment procedure was considered the best possible alternative to determine the water solubility of the test substance. It will be reported as a range, i.e. 0.764 – 1.53 mg/l.
Any other information on results incl. tables
Since the test substance was not detected in any of the aqueous solutions after three- and four-times centrifugation, this was not considered to be a suitable sample treatment. It was suspected that the test substance adsorbed to the wall of the centrifugation vials and was lost in the first two centrifugation steps.
No test substance was detected in the pre-treated samples from the blank water mixture.Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The flask method was chosen for the determination of the water solubility of LE 5288. The water solubility of the test substance at 20.0°C +/- 0.5°C was 0.764 – 1.53 x 10-3 g/l. The pH of the aqueous sample after 72 hours stirring was 7.8. - Executive summary:
The water solubilty of the substance wasd determined according to OECD Guidelline 105. The flask method was chosen for the determination of the water solubility of LE 5288. The water solubility of the test substance at 20.0°C +/- 0.5°C was 0.764 – 1.53 x 10-3 g/l. The pH of the aqueous sample after 72 hours stirring was 7.8.
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