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EC number: 236-537-4 | CAS number: 13423-15-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Similar to guideline method, but predates GLP. Purity of test compound not provided and observation period terminated after 14 days instead of 21. Results are sufficient in detail for evaluation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Purity of test substance not reported and observation terminated at 14 days instead of 21 and only two animals were tested.
- GLP compliance:
- not specified
- Remarks:
- study predates GLP
Test material
- Reference substance name:
- Tetrahydro-3-methylfuran
- EC Number:
- 236-537-4
- EC Name:
- Tetrahydro-3-methylfuran
- Cas Number:
- 13423-15-9
- Molecular formula:
- C5H10O
- IUPAC Name:
- tetrahydro-3-methylfuran
- Details on test material:
- Furan, 3-methyl tetrahydro-
100% active ingredient, stabilized with 0.025 wt. % Ionol®
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Albino
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- Single application, one eye wased after 20 seconds while other eye was unwashed.
- Observation period (in vivo):
- Observations made at one and four hours and at 1,2,7,and 14 days
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- A dose of 0.1 ml of terahydro-3-methylfuran was instilled into the right conjunctival sac of each of two albino rabbits. After 20 second, one exposed eye was washed with tap water for one minute while the other was not washed. Observation of the cornea, iris, and conjuctiva were made with a hand slit lamp at the appropriate times, 5% fluorescein stain and biomicroscope were used for these examinations.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- of animals 1and 2 (individually), unwashed eye
- Time point:
- other: 24-72 hours
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- of animals 1 and 2 (individually), unwashed eye
- Time point:
- other: 24-72 hours
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- of animals 1 and 2 (individually), unwashed eye
- Time point:
- other: 24-72 hours
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- of animals 1 and 2 (individually), unwashed eye
- Time point:
- other: 24-72 hours
- Score:
- 2.67
- Max. score:
- 4
- Reversibility:
- not specified
Any other information on results incl. tables
Dose |
Treatment of Eyes |
Ocular Effects |
||
Cornea |
Iris |
Conjunctiva |
||
0.1 ml of Product* |
Not washed |
Moderate but deep injury at 1-3 days; mild injury with superficial vascularization at 7 days; small areas of haziness under magnification at 14 days. |
Minimal congestion 1-4 hours; moderate iritis 1-3 days. |
Mild redness 1 hour - 3 days, minimal at 7 days; severe to moderate swelling 1-4 hours, mild 1-3 days, minimal at 7 days; copious discharge 1 hour - 3 days, minimal at 7 days**. |
0.1 ml of Product* |
Washed (after 20 seconds of exposure) |
Moderate but deep injury 1-3 days; small area of haziness under magnification 7-14 days. |
Minimal to mild congestion 1-4 hours: moderate iritis 1-2 days: mild iritis at 3 days. |
Mild redness 1 hour - 3 days; moderate swelling 1-4 hours, mild 1-2 days, minimal at 3 days; copious discharge 1 hour - 2 days, mild at 3 days***. |
* 3-methyl-tetrahydrofuran, stabilized with 0.025 wt. % Ionol® **Fibrin in discharge 1-3 days. *** Fibrin in discharge 1-2 days. |
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- 3 -Methyltetrahydrofuran produced moderate but penetrating corneal damage, moderate iritis and conjuctivitis in both rabbit eyes that were not promptly washed after dosing and in a rabbit eye that was washed 20 seconds after contact. Both corneas still had mild damage at 14 days.
- Executive summary:
Tetrahydro-3-methylfuran (3meTHF) should be regarded as capable of causing irreversible effects on the eye based on in vivo administration of 0.1 ml of 3meTHF into the right conjunctival sac of each of two albino rabbits. After 20 seconds, one exposed eye was washed with tap water for one minute while the other was not washed. Observation of the cornea, iris, and conjuctiva were made with a hand slit lamp at the appropriate times, 5% fluorescein stain and biomicroscope were used for these examinations. 3meTHF produced moderate but penetrating corneal damage, and moderate iritis and conjuctivitis in both rabbit eyes that were not promptly washed after dosing and in a rabbit eye that was washed 20 seconds after contact. Both corneas still had mild damage at 14 days.
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