Registration Dossier
Registration Dossier
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EC number: 233-662-6 | CAS number: 10294-54-9
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
In accordance with the Guidance on Information Requirements and Chemical Safety Assessment, chapter R.7c (ECHA, 2008) the profile on basic toxicokinetics of cesium sulphate was derived from physico-chemical data as well as from toxicological data of cesium sulphate and structurally related cesium salts.
Due to its physico-chemical properties and the observed systemic toxicity at least at high concentrations of cesium compounds cesium ions will be well absorbed within the GI tract and become bioavailable following oral administration. This estimation is confirmed by literature data. It is textbook knowledge that sulphate ions are resorbed via sodium-coupled secondary active transport which is limited and not reaching the efficiency of 100 %.
Based on its physico-chemical properties and absence of toxicity in acute dermal toxicity studies very limited absorption into the systemic circulation is expected after dermal application. Literature data support this estimation.
Considering the very low vapour pressure, the resulting low volatility and the fact that the chemical exist as a crystalline solid at room temperature with particle sizes well above 100 μm it is unlike that the substance will be inhaled either in vapour form or as dust particles under use conditions.
Based on the physico-chemical properties cesium sulphate more precisely the respective ions are readily distributed throughout the body. This is confirmed by the presence of target organs in subacute and subchronic studies and literature data.
Due to the physico-chemical properties and according to available literature it is not likely that the respective ions of cesium sulphate will undergo further enzymatic biotransformation processes or will reveal an accumulation potential.
Considering the physico-chemical properties and the available literature cesium sulphate more precisely the respective ions are mainly urinary excreted.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
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