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EC number: 213-986-4 | CAS number: 1071-22-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- not known
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted in accordance with an appropriate OECD test guideline and in compliance with GLP, using a related test substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: USEPA OPPTS 870.3650
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 422
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- 3-(triethoxysilyl)propiononitrile
- EC Number:
- 213-050-5
- EC Name:
- 3-(triethoxysilyl)propiononitrile
- Cas Number:
- 919-31-3
- IUPAC Name:
- 3-(triethoxysilyl)propanenitrile
- Details on test material:
- 3-(triethoxysilyl)propanenitrile (CAS # 919-31-3); purity
was >97.8 %
Lot 4A-4363-BS
Colorless to clear liquid
expiration 18-APR-2005
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: HanBrl:WIST (SPF)
- Details on test animals or test system and environmental conditions:
- Rats were obtained from RCC Ltd Laboratory Animal Services, Fullinsdorf, Switzerland.
Animals were a minimum of 8 weeks of age at delivery. Males were 227-271 grams and females were 165-216 grams. Animals were acclimated for 7 days prior to pairing, under test conditions with an evaluation of the health status. Animals rooms were air conditioned with 10-15 air changes per hour; the environment was monitored continously with recordings of temperature and relative humidity, 12 hours artificial fluorescent light/12 hours dark with background music played at a centrally defined low volume for at least 8 hours during the light period. Animals were housed in Makrolon (R) cages with wire mesh tops and standard granulated softwood bedding. Pelleted standard rat/mouse maintenance diet was available ad libitum. Tap water from Fullinsdorf in bottles was available ad libitum.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on exposure:
- The test item was administered once daily, by gavage. All animals received a dose volume of 2 ml/kg body weight with a daily adjustment of the individual volume to the actual body weight. Control animals were dosed with the vehicle alone.
- Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- Samples for determination of actual test item concentrations, stability (7 day) and homogeneity in the prepared mixtures were taken on the first day of preparation. Samples for determination of actual test item concentrations and homogeneity were also taken on one occasion during the gestation period. Analysis were performed using a Gas Chromatographic method.
- Details on mating procedure:
- After a pre-paring period of 14 days, males and females in the Reproductive groups were paired overnight, in the ratio of 1 male to 1 female. The female was placed with the same male until mating occured or two weeks had elapsed. The day on which spermatozoa was observed was designated day 0 post coitum. After mating was asecertained, the animals were separated and housed individually. The feamles were allowed to litter and rear their progeny to day 4 of lactation.
- Duration of treatment / exposure:
- Pre-mating (14 days), mating, gestation, and postpartum days 1-3 for a maximum total of 44 days depending on duration of mating phase.
- Frequency of treatment:
- daily
- Duration of test:
- Exposure period: Premating (14 days), mating, gestation, and postpartum days 1-3 for a maximum total of 44 days depending on
duration of mating phase.
Premating exposure period (males): 14 days
Premating exposure period (females): 14 days
Duration of test: up to a maximum of 44 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100, 500, and 1000 mg/kg bw/day
Basis:
- No. of animals per sex per dose:
- 10/sex/dose
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Sex: male/female
Duration of test: up a maximum total of 44 days
Animals of both sexes received test article for 14 days prior to pairing and during pairing period. Daily dosing of the females was
continued throughout pregnancy and up to day 3 of lactation. Males were dosed for a minimum of 28 days.
Examinations
- Maternal examinations:
- The dams and pups were observed daily for survival and behavioral abnormalities in nursing. No tissues were collected from the dams
or pups for microscopic examination. - Ovaries and uterine content:
- Organs examined at necropsy (macroscopic and microscopic): The number of implantation sites and corpora lutea were determined
at necropsy. - Fetal examinations:
- Pup litter size, any gross abnormalities and weight, sex ratios, pup viability, litter weight gain, and macroscopic observations. The dams and
pups were observed daily for survival and behavioral abnormalities in nursing. Macroscopic examination was performed at necropsy for the
pups. No tissues were collected from the dams or pups for microscopic examination. - Statistics:
- Statistical methods: Mean and standard deviations of data of various parameters were calculated. Univariate one-way analysis of variance was
used to assess the significance of intergroup differences. Dunnett t-test, based on a pooled variance estimate, was used for intergroup
comparisons. The Steel test (rank test) was applied when the data could not be assumed to follow a normal distribution. Fisher's Exact test
for 2x2 tables was applied if the variables could be dichotomized without loss of information. For pup data, the litter is the appropriate unit
for statistical comparison. Statistically significant probabilities are reported at either the p<0.05 or p<0.01 levels. - Indices:
- Gonadal function, mating behavior, conception, development of the conceptus and parturition
Results and discussion
Results: maternal animals
Maternal developmental toxicity
- Details on maternal toxic effects:
- Maternal toxic effects:no effects
Effect levels (maternal animals)
- Dose descriptor:
- NOAEL
- Effect level:
- 1 000 mg/kg bw/day
- Basis for effect level:
- other: maternal toxicity
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:no effects
Details on embryotoxic / teratogenic effects:
Result: No treatment-related effects were observed in any of the developmental parameters evaluated. No abnormal findings were noted in
any treated groups during 4 days post-partum. No treatment-related effects were observed in any of the developmental parameters evaluated.
" Fetal data, provide at a minimum qualitative descriptions of responses where dose related effects were seen:
¢ Litter size and weights: Not affected by treatment.
¢ Number viable (number alive and number dead): Not affected by treatment.
¢ Sex ratio: Not affected by treatment.
¢ Grossly visible abnormalities, external, soft tissue and skeletal abnormalities: None.
Effect levels (fetuses)
- Dose descriptor:
- NOAEL
- Effect level:
- 1 000 mg/kg bw/day
- Basis for effect level:
- other: teratogenicity
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Based on the results of this screening study, the NOAEL for
maternal and developmental toxicity of
3-(triethoxysilyl)propanenitrile in the rat
via oral dosing was determined to be 1000 mg/kg bw/day.
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