Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 213-986-4 | CAS number: 1071-22-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The result is sourced from secondary literature (IUCLID 2000 data set). The original reference was not available for review and no further information is available.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 962
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3-(trichlorosilyl)propiononitrile
- EC Number:
- 213-986-4
- EC Name:
- 3-(trichlorosilyl)propiononitrile
- Cas Number:
- 1071-22-3
- Molecular formula:
- C3H4Cl3NSi
- IUPAC Name:
- 3-(trichlorosilyl)propanenitrile
- Details on test material:
- No information
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: No data
- Vehicle:
- not specified
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: No toxic effects reported at 2000 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In a very limited summary of an acute oral toxicity study (reliability score 4) in IUCLID 2000, the LD50 for 3-(trichlorosilyl)propiononitrile was greater than 2000 mg/kg bw in rats.
- Executive summary:
In a very limited summary of an acute oral toxicity study (reliability score 4) in IUCLID 2000, the LD50 for 3-(trichlorosilyl)propiononitrile was greater than 2000 mg/kg bw in rats. No clinical signs of toxicity were observed at this limit dose. No further details are available.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
