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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to Guideline study. Only basic data given.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1983
Report Date:
1983

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
Limited information concerning test conditions and/or experimental methods.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Sodium laurylsulfate
- Physical state: White powder
- Analytical purity: >98% a.i.
- Lot / Batch No. : 68/3
- Storage condition of test material: No data

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals and environmental conditions:
According to guideline.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
no data
No. of animals per sex per dose:
5-10
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 200 mg/kg bw
Based on:
test mat.
Sex:
female
Dose descriptor:
LD50
Effect level:
977 mg/kg bw
Based on:
test mat.
Sex:
male
Dose descriptor:
LD50
Effect level:
1 427 mg/kg bw
Based on:
test mat.
Mortality:
Occurred, but no detailed data.
Clinical signs:
Diarrhoea, spastic gait, decreased activity, lateral position, hunched posture, laboured respiration, coma, death.
Body weight:
Not stated.
Gross pathology:
Necropsy of died animals: haemorrhages in gastro-intestinal tract and vascular congestion in the liver
Necropsy of survivors: no adverse effects
Other findings:
Not stated.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU