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EC number: 201-174-2
CAS number: 79-07-2
In a 30 days repeated dose study, 5 groups and 1 control
group of each 5 female rabbits onderwent daily intravenous injection in
the ear vein with 1mL/kg bw of Chloroacetamide at different
concentrations in order to get doses of 2, 10, 25, 50 and 100 mg/kg bw.
On all animals hematology and urinalysis was examined before the start
and at the end of the study. Behavior of the animals was observed daily
and body weight 3 times weekly. At the end of testing, after 5 days
recovery, all survivors were killed and gross pathology and
histopathology was performed. All animals that died during the study
also underwent gross pathology and histopathology except that no
histopathology was done at the high dosed animals that died at first or
second application. At doses of 2 and 10 mg/kg bw no toxic effects were
observed. Intravenous application of Chloroacetamid caused dose
dependent paralysis and death from a dose of 25 mg/kg or higher.
Decreased hemoglobin was seen at a dose of 25 mg/kg bw (in the 50 and
100 mg/kg bw dose groups no hematology or urinalysis was possible
because all animals died). The NOAEL for Chloroacetamide in this study
was determined to be 10 mg/kg bw/day.
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