Registration Dossier
Registration Dossier
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EC number: 208-797-9 | CAS number: 542-05-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The target chemical 3-oxoglutaric acid and the read across chemical belong to the same category; that of “dicarboxylic acid”. Both the chemicals share physico-chemical properties within an acceptable range as well as environmental fate properties and aquatic toxicity properties thereby qualifying for suitable read-across. In general, the most striking pattern across the two chemicals is their low toxicity profile.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- RTECS Number : MA3740000
- Author:
- RTECS database
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances); HPV199 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Dicarboxylic Acid Category.pdf (http://www.epa.gov/HPV/pubs/summaries/viewsrch.htm) Volume(issue)/page/year:2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from RTECS database
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Glutaric acid
- EC Number:
- 203-817-2
- EC Name:
- Glutaric acid
- Cas Number:
- 110-94-1
- IUPAC Name:
- glutaric acid
- Details on test material:
- - Name of test material : glutaric acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- 2750 mg/kg
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 750 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Behavioral - tremor Gastrointestinal - gastritis Gastrointestinal - hypermotility, diarrhea
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Acute toxicity via oral route in rat for glutaric acid is LD50: 2750 mg/kg
- Executive summary:
Acute toxicity via oral route in rat for glutaric acid is LD50: 2750 mg/kg
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