Registration Dossier
Registration Dossier
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EC number: 208-797-9 | CAS number: 542-05-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The target chemical 3-oxoglutaric acid and the read across chemical belong to the same category; that of “dicarboxylic acid”. Both the chemicals share physico-chemical properties within an acceptable range as well as environmental fate properties and aquatic toxicity properties thereby qualifying for suitable read-across. In general, the most striking pattern across the two chemicals is their low toxicity profile.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- RTECS Number : MA3740000
- Author:
- RTECS database
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances);HPV199 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Dicarboxylic Acid Category.pdf (http://www.epa.gov/HPV/pubs/summaries/viewsrch.htm) Volume(issue)/page/year: 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from RTECS database - Standard daize test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Glutaric acid
- EC Number:
- 203-817-2
- EC Name:
- Glutaric acid
- Cas Number:
- 110-94-1
- IUPAC Name:
- glutaric acid
- Details on test material:
- - Name of test material : glutaric acid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- not specified
- Controls:
- not specified
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks on result:
- other: Dose data : 100 mg
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Eye irritation of glutaric acid in rabbits was examined at dose concentration of 100 mg based on which it is assumed that glutaric acid shall have slight irritation potential to the eye
- Executive summary:
Eye irritation of glutaric acid in rabbits was examined at dose concentration of 100 mg based on which it is assumed that glutaric acid shall have slight irritation potential to the eye
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