Registration Dossier
Registration Dossier
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EC number: 216-074-4 | CAS number: 1490-04-6
Endpoint summary
Administrative data
Description of key information
The studies on acute oral toxicity were not performed according to guideline methods. However, the number of treated animals and the used protocols are scientifically acceptable to evaluate this endpoint sufficiently.
A valid study on acute inhalation toxicity according OECD TG 403 was conducted
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 3 180 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 5 289 mg/m³ air
Additional information
Studies on rats and mice showed acute oral toxicity with LD50 values higher than 2000 mg/kg bw with one exception were a value of 940 mg/kg bw was found in an insufficient documented mutagenic evaluation study.
In the acute inhalation toxicity study on rats a LC50 (aerosol, 4h) = 5289 mg/m³ was determined.
In a study from a secondary source a LD50 > 5000 mg/kg bw was ffound for acute dermal toxicity.
Justification for classification or non-classification
The acute oral toxicity studies demonstrated a low systemic toxicity with LD50 values higher than 2000 mg/kg bw.
In the acute inhalation study a LC50 > 5000 mg/m³ was (rat, aerosol, 4 h) was determined.
A classification is therefore noit justified.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
