Registration Dossier
Registration Dossier
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EC number: 216-074-4 | CAS number: 1490-04-6
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: suffient documented for evaluation
Data source
Reference
- Reference Type:
- publication
- Title:
- Quantitative studies of ß-oxidation - IV. the metabolism of conjugated glucuronic acids
- Author:
- Quick AJ
- Year:
- 1 924
- Bibliographic source:
- J Biol Chem 61, 679-683
Materials and methods
- Objective of study:
- toxicokinetics
- Principles of method if other than guideline:
- menthol (unspecified isomer) were given to rabbits by stomach tube, and menthol glucuronic acid measured in the urine
- GLP compliance:
- no
Test material
- Reference substance name:
- DL-menthol
- EC Number:
- 216-074-4
- EC Name:
- DL-menthol
- Cas Number:
- 1490-04-6
- Molecular formula:
- C10H20O
- IUPAC Name:
- 2-isopropyl-5-methylcyclohexanol
- Details on test material:
- menthol (unspecified isomer)
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- menthol glucuronic acid
Any other information on results incl. tables
Menthol glycuronic acid appeared in the urine of rabbits in less than an hour after feeding menthol, and 90 per cent of the conjugated acid was found to be excreted in 6 hours when 2 g of menthol were feed. Even when larger doses were given over 90 per cent of the total amount excreted appeared in the urine during the first 24 hours
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
- Executive summary:
When 2 g of menthol (unspecified isomer) were given to rabbits by stomach tube, menthol glucuronic acid appeared in
the urine in less than an hour after the administration of the test substance and 90 % of the conjugated acid was found
to be excreted in 6 h; when 3.5 g were given, over 90 % of the total amount excreted appeared in the urine during the
first 24 h
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